Dukers N H, Bruisten S M, van den Hoek J A, de Wit J B, van Doornum G J, Coutinho R A
Division of Public Health and Environment, Municipal Health Service Amsterdam, The Netherlands.
Am J Epidemiol. 2000 Oct 1;152(7):666-73. doi: 10.1093/aje/152.7.666.
The objective of this study was to evaluate whether the change in sexual behavior among homosexual men observed after the start of the acquired immunodeficiency syndrome epidemic resulted in a change in herpes simplex virus (HSV) seroprevalence in this group over time. In a cross-sectional study, the prevalence of herpesvirus types 1 (HSV1) and 2 (HSV2) was determined at study entry in 1984-1985 and 1995-1997 among 532 young (aged < or = 30 years) homosexual men participating in the Amsterdam Cohort Studies on HIV/AIDS. Risk factors for the presence of HSV antibodies, including human immunodeficiency virus infection, were evaluated, and their influence on HSV prevalence over time was assessed. A strong decrease in HSV1 and HSV2 seroprevalence, from 80.6% to 59.0% and from 51.3% to 19.0%, respectively, was observed between the two time periods. This decrease was not markedly influenced by various demographic and socioeconomic factors. After data were controlled for several markers of sexual activity (such as number of sex partners, human immunodeficiency virus infection, and past episode(s) of gonorrhea), it appeared that the decline in HSV seroprevalence was explained by a concurrent decrease in the presence of these markers. The authors conclude that among young homosexual men in this study, the strong decrease in HSV seroprevalence was associated with a concurrent shift in sexual behavior. Furthermore, these data suggest an increasing sexual component in HSV1 transmission over time.
本研究的目的是评估在获得性免疫缺陷综合征流行开始后观察到的男同性恋者性行为变化是否导致该群体中单纯疱疹病毒（HSV）血清阳性率随时间发生变化。在一项横断面研究中，于1984 - 1985年和1995 - 1997年研究开始时，对参与阿姆斯特丹艾滋病毒/艾滋病队列研究的532名年轻（年龄≤30岁）男同性恋者确定了1型疱疹病毒（HSV1）和2型疱疹病毒（HSV2）的流行率。评估了包括人类免疫缺陷病毒感染在内的HSV抗体存在的危险因素，并评估了它们对HSV流行率随时间的影响。在两个时间段之间观察到HSV1和HSV2血清阳性率大幅下降，分别从80.6%降至59.0%，从51.3%降至19.0%。这种下降并未受到各种人口统计学和社会经济因素的显著影响。在对性活动的几个指标（如性伴侣数量、人类免疫缺陷病毒感染和既往淋病发作情况）进行数据控制后，似乎HSV血清阳性率的下降可以用这些指标的同时减少来解释。作者得出结论，在本研究的年轻男同性恋者中，HSV血清阳性率的大幅下降与性行为的同时转变有关。此外，这些数据表明随着时间推移，HSV1传播中的性传播成分在增加。
