Kuiken C L, van Griensven G J, de Vroome E M, Coutinho R A
Academic Medical Center, Department of Virology, Amsterdam, The Netherlands.
Am J Epidemiol. 1990 Sep;132(3):523-30. doi: 10.1093/oxfordjournals.aje.a115688.
In Amsterdam, The Netherlands, a cohort of 982 homosexual and bisexual men has been studied since 1984. Of these, 238 men had antibodies to the human immunodeficiency virus at the onset of the study, and 84 men seroconverted while under study. For each of these seroconversions, two participants who remained seronegative were chosen for comparison, taking the seroconversion date as a reference. This offered an opportunity to study any changes that may have occurred longitudinally, i.e., over time. Risk factors for seroconversion were studied along with changes in sexual behavior relative to the moment of seroconversion. The number of different partners in anogenital receptive intercourse and a history of syphilis or anogenital herpes simplex were found to be predictors for human immunodeficiency virus seroconversion. The data suggest that, prior to seroconversion, there is a peak in riskful sexual behavior and that the "decline" often observed immediately after seroconversion is, in fact, an indication of a return to "normal" sexual activity.
自1984年以来，在荷兰阿姆斯特丹对一组982名同性恋和双性恋男性进行了研究。其中，238名男性在研究开始时就已感染人类免疫缺陷病毒抗体，84名男性在研究期间发生了血清转化。对于每一次血清转化，选择两名仍为血清阴性的参与者进行比较，以血清转化日期作为参照。这为研究可能随时间纵向发生的任何变化提供了机会。研究了血清转化的危险因素以及相对于血清转化时刻性行为的变化。发现肛门生殖器接受性性交中不同性伴侣的数量以及梅毒或肛门生殖器单纯疱疹病史是人类免疫缺陷病毒血清转化的预测因素。数据表明，在血清转化之前，高危性行为会出现一个高峰，而血清转化后经常立即观察到的“下降”实际上表明性行为恢复到了“正常”水平。
