Siegel D, Golden E, Washington A E, Morse S A, Fullilove M T, Catania J A, Marin B, Hulley S B
Center for AIDS Prevention Studies, University of California, San Francisco.
JAMA. 1992 Oct 7;268(13):1702-8.
To examine the extent and correlates of infection with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in an inner-city community, we studied the prevalence of antibodies to these viruses and their association with risk behaviors in a representative sample of unmarried white, black, and Hispanic adults living in San Francisco, Calif.
Cross-sectional, community-based, random household survey.
In 1988 and 1989, we surveyed 1770 unmarried men and women aged 20 to 44 years from three San Francisco neighborhoods of varying geographic and cultural characteristics.
HSV-1 and HSV-2 antibodies based on an immunodot assay using type-specific glycoproteins gG-1 and gG-2.
Of blood samples from 1212 participants available for testing, 750 (62%) had HSV-1 antibodies and 400 (33%) had HSV-2 antibodies. After controlling for other variables, HSV-1 antibody was significantly correlated (P less than .05) with older age (in heterosexual men, women, and homosexually active men), less education (in heterosexual men and women), and Hispanic (especially those not born in the United States) or black race. HSV-2 antibody was significantly correlated (P less than .05) with female gender, number of lifetime sexual partners and older age (in heterosexual men and women), and low levels of education and black or Hispanic race (in women). Among those with antibody to HSV-2, only 28 (19%) of 149 men and 32 (13%) of 251 women reported a history of genital herpes. However, most men (62%) and women (84%) who reported a history of genital herpes had HSV-2 antibodies. We observed a similar pattern (low sensitivity and moderate specificity) for a history of facial herpes and the presence of HSV-1 antibodies. After controlling for other variables, HSV-2 antibodies were associated with a lower frequency of HSV-1 antibodies among homosexual men infected with the human immunodeficiency virus.
HSV-1 antibodies were found in nearly two thirds of single urban adults and were most common among Hispanics not born in the United States. HSV-2 antibodies were found in one third of this population and were associated with risk behaviors for sexually transmitted diseases. For both facial and genital herpes infections, self-reporting of infection was very insensitive and moderately specific.
为了研究1型单纯疱疹病毒（HSV - 1）和2型单纯疱疹病毒（HSV - 2）在一个市中心社区的感染程度及其相关因素，我们在加利福尼亚州旧金山的一个具有代表性的未婚白人、黑人和西班牙裔成年人样本中，研究了这些病毒抗体的流行情况及其与危险行为的关联。
基于社区的横断面随机家庭调查。
在1988年和1989年，我们对来自旧金山三个具有不同地理和文化特征社区的1770名年龄在20至44岁的未婚男女进行了调查。
基于使用型特异性糖蛋白gG - 1和gG - 2的免疫斑点试验检测HSV - 1和HSV - 2抗体。
在可供检测的1212名参与者的血样中，750人（62%）有HSV - 1抗体，400人（33%）有HSV - 2抗体。在控制了其他变量后，HSV - 1抗体与年龄较大（在异性恋男性、女性和有同性性行为的男性中）、受教育程度较低（在异性恋男性和女性中）以及西班牙裔（尤其是那些非在美国出生的）或黑人种族显著相关（P < 0.05）。HSV - 2抗体与女性性别、终身性伴侣数量、年龄较大（在异性恋男性和女性中）以及教育程度低和黑人或西班牙裔种族（在女性中）显著相关（P < 0.05）。在有HSV - 2抗体的人中，149名男性中只有28人（19%）和另外251名女性中只有32人（13%）报告有生殖器疱疹病史。然而，大多数报告有生殖器疱疹病史的男性（62%）和女性（84%）都有HSV - 2抗体。我们观察到面部疱疹病史和HSV - 1抗体存在情况也有类似模式（低敏感性和中等特异性）。在控制了其他变量后，在感染人类免疫缺陷病毒的同性恋男性中，HSV - 2抗体与HSV - 1抗体的较低频率相关。
在近三分之二的城市单身成年人中发现了HSV - 1抗体，在非在美国出生的西班牙裔中最为常见。在这一人群的三分之一中发现了HSV - 2抗体，并且其与性传播疾病的危险行为相关。对于面部和生殖器疱疹感染，感染的自我报告非常不敏感且特异性中等。
