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A new approach to anti-inflammatory drugs.

作者信息

Higgs G A, Flower R J, Vane J R

出版信息

Biochem Pharmacol. 1979 Jun 15;28(12):1959-61. doi: 10.1016/0006-2952(79)90651-8.

DOI:10.1016/0006-2952(79)90651-8
PMID:110332
Abstract
摘要

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A new approach to anti-inflammatory drugs.
Biochem Pharmacol. 1979 Jun 15;28(12):1959-61. doi: 10.1016/0006-2952(79)90651-8.
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Garden rue inhibits the arachidonic acid pathway, scavenges free radicals, and elevates FRAP: role in inflammation.芸香抑制花生四烯酸途径，清除自由基，并提高FRAP：在炎症中的作用。
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Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa.选择性抑制炎性渗出物和胃黏膜中前列腺素的生成。
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[Antiphlogistic effectiveness of combinations of inhibitors of phospholipase A2, cyclooxygenase and lipoxygenases of the arachidonic acid cascade].
Pharmazie. 1986 Apr;41(4):260-2.
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[Simultaneous and sequential inhibition of the arachidonic acid cascade by inhibitors of phospholipase A2, cyclooxygenase and lipoxygenases in carrageenan edema and adjuvant arthritis in the rat].
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[The influence in the rat of counter-irritation by turpentine on the leukocyte content of exudates induced by sponge implants].[松节油反刺激对大鼠海绵植入诱导渗出液白细胞含量的影响]
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A new antiinflammatory compound, timegadine (N-cyclohexyl-N"-4-[2-methylquinolyl]-N'-2-thiazolylguanidine), which inhibits both prostaglandin and 12-hydroxyeicosatetraenoic acid (12-HETE) formation.一种新的抗炎化合物，替马加定（N-环己基-N''-4-[2-甲基喹啉基]-N'-2-噻唑基胍），它能抑制前列腺素和12-羟基二十碳四烯酸（12-HETE）的形成。
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Measurement of arachidonic acid liberation in thrombin-stimulated human platelets. Use of agents that inhibit both the cyclooxygenase and lipoxygenase enzymes.凝血酶刺激的人血小板中花生四烯酸释放的测定。使用同时抑制环氧化酶和脂氧合酶的试剂。
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Effects of anti-inflammatory drugs on rat paw oedema and leukocyte migration.
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Prostaglandins, leucocytes and non-steroidal anti-inflammatory drugs.前列腺素、白细胞与非甾体抗炎药
Pol J Pharmacol Pharm. 1974 Jan-Apr;26(1):25-36.

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Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.非甾体抗炎药作为组成型和诱导型环氧化酶抑制剂的选择性
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Suppressive effect of 2-phenyl-4-quinolone (YT-1) on hind-paw edema and cutaneous vascular plasma extravasation in mice.2-苯基-4-喹诺酮（YT-1）对小鼠后爪水肿和皮肤血管血浆外渗的抑制作用。
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Relative roles of nitric oxide and cyclo-oxygenase and lipoxygenase products of arachidonic acid in the contractile responses of rat renal arcuate arteries.一氧化氮、花生四烯酸的环氧化酶和脂氧化酶产物在大鼠肾弓状动脉收缩反应中的相对作用。
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