Kaur S J, Grover I S, Kumar S
Department of Botanical Sciences, Guru Nanak Dev University, 143 005, Amritsar, India.
Food Chem Toxicol. 2000 Dec;38(12):1113-9. doi: 10.1016/s0278-6915(00)00104-6.
A fraction isolated from Terminalia arjuna was studied for its antimutagenic effect against 4-nitro-o-phenylenediamine (NPD) in TA98, sodium azide in TA100 and 2-aminofluorene (2AF, S9-dependent), a promutagen, in both TA98 and TA 100 tester strains of Salmonella typhimurium using the Ames assay. The fraction inhibited the mutagenicity of 2AF very significantly in both strains while the revertant colonies induced by NPD and sodium azide were reduced moderately. 1H-NMR, 13C-NMR, IR and UV-spectroscopic data of the fraction revealed it to be tannin in nature.
对从诃子中分离出的一个组分进行了研究，采用Ames试验，考察其对鼠伤寒沙门氏菌TA98菌株中4-硝基邻苯二胺（NPD）、TA100菌株中叠氮化钠以及TA98和TA100测试菌株中作为前诱变剂的2-氨基芴（2AF，依赖S9）的抗诱变作用。该组分在两种菌株中均非常显著地抑制了2AF的诱变性，而由NPD和叠氮化钠诱导的回复突变菌落则适度减少。该组分的1H-NMR、13C-NMR、红外光谱和紫外光谱数据表明其本质为单宁。
