Volavsek M, Masera A, Ovcak Z
Medical Faculty, University of Ljubljana, Institute of Pathology Korytkova 2, Ljubljana, 1000, Slovenia.
Pathol Oncol Res. 2000;6(3):191-6. doi: 10.1007/BF03032372.
Incidental prostatic carcinoma (ICP) has good prognosis related to low stage at diagnosis. Few rogressive cases demanding aggressive treatment need early identification. Neoangiogenesis proved its predictive role in prostatic carcinoma after radical prostatectomy. To reveal its value in ICP authors investigated specimens after transurethral resection of prostate (TURP). Retrospective study was performed on 68 ICP diagnosed in years 1985 1989. Microvessels highlighted by factor VIII were counted in a x200 microscope field (0,8012 mm 2 ) in most active areas of neovascularisation. Microvessel count was correlated with tumor differentiation degree, Gleason score, disease stage, and patients survival in at least 9 years after diagnosis. Higher maximal microvessel counts were associated with lower degree of tumor differentiation (p=0,005), Gleason score (p=0,001), and disease stage (0,003). No association with disease progression and patients survival was found. Mean microvessel counts showed less significant values when correlated with tumor differentiation degree (p=0,003) and Gleason score (p=0, 01), and no correlation with other variables. Microvessel density in TURP specimens of ICP retains its prognostic value already demonstrated in carcinoma of peripheral prostatic lobes. Maximal microvessel counts were prognostically more reliable than mean values.
偶发性前列腺癌（ICP）因诊断时分期较低而预后良好。少数需要积极治疗的进展性病例需要早期识别。新血管生成已被证明在前列腺癌根治术后具有预测作用。为揭示其在ICP中的价值，作者对经尿道前列腺切除术（TURP）后的标本进行了研究。对1985年至1989年诊断的68例ICP进行了回顾性研究。在新血管生成最活跃的区域，在200倍显微镜视野（0.8012平方毫米）中对由因子VIII突出显示的微血管进行计数。微血管计数与肿瘤分化程度、Gleason评分、疾病分期以及诊断后至少9年的患者生存率相关。微血管最大计数越高，与肿瘤分化程度越低（p = 0.005）、Gleason评分越低（p = 0.001）和疾病分期越低（p = 0.003）相关。未发现与疾病进展和患者生存率相关。平均微血管计数在与肿瘤分化程度（p = 0.003）和Gleason评分（p = 0.01）相关时显示出不太显著的值，与其他变量无相关性。ICP的TURP标本中的微血管密度保留了其在外周前列腺叶癌中已证明的预后价值。微血管最大计数在预后上比平均值更可靠。
