Flower R W, Lim J I
Department of Ophthalmology, University of Maryland School of Medicine Baltimore, Maryland, USA.
J Fr Ophtalmol. 2000 Oct;23(8):756-62.
To demonstrate an indocyanine green (ICG) angiography-based clinical method for characterizing choroidal blood flow and for detecting changes in choroidal circulation patterns, and by use of that method, to demonstrate that pentoxifylline affects choroidal blood flow.
High-speed ICG angiography was performed in rhesus monkeys before and after intravenous administration of pentoxifylline or saline (which served as a control) while monitoring blood pressure and heart rate. From these data, three-dimensional surface maps indicating the instantaneous relative distribution of choroidal blood flow during the peak of intra-ocular pressure pulse systole in a 30 degrees field, centered on the macula, were generated to characterize the state of the choroidal circulation at various times during the experiments.
Comparisons of the 3-dimentional surface maps consistently indicated an increase in sub-macular choroidal blood flow occurring within 5 to 10 minutes post-pentoxifylline injection, with a gradual return to baseline level 20-40 minutes later. Injection of equal volumes of saline produced no changes in choroidal blood flow.
Posterior-pole choroidal blood flow can be characterized as by a three-dimensional surface representing the instantaneous relative distribution of choroidal blood flow during the peak of intra-ocular pressure pulse systole. Pentoxifylline does, at least transiently, increase sub-macular choroidal blood flow.
展示一种基于吲哚菁绿（ICG）血管造影的临床方法，用于表征脉络膜血流并检测脉络膜循环模式的变化，并通过该方法证明己酮可可碱对脉络膜血流的影响。
在恒河猴静脉注射己酮可可碱或生理盐水（作为对照）前后进行高速ICG血管造影，同时监测血压和心率。根据这些数据，生成三维表面图，显示以黄斑为中心的30度视野内眼内压脉冲收缩期峰值时脉络膜血流的瞬时相对分布，以表征实验过程中不同时间的脉络膜循环状态。
三维表面图的比较一致表明，己酮可可碱注射后5至10分钟内，黄斑下脉络膜血流增加，20至40分钟后逐渐恢复至基线水平。注射等量生理盐水对脉络膜血流无影响。
后极部脉络膜血流可以通过代表眼内压脉冲收缩期峰值时脉络膜血流瞬时相对分布的三维表面图来表征。己酮可可碱至少能短暂增加黄斑下脉络膜血流。
