Hamard P, May F, Quesnot S, Hamard H
Centre du Glaucome, CHNO des Quinze-Vingts, 75012 Paris.
J Fr Ophtalmol. 2000 Oct;23(8):773-80.
To evaluate the success rate of contact diode transscleral cyclophotocoagulation (TSCPC) in pediatric refractory glaucoma.
and method: Twenty-eight eyes of 28 patients (age range 5 months to 26 years) with medical and surgical refractory pediatric glaucoma due to primary congenital glaucoma (group 1, 20 eyes) or aphakic congenital glaucoma (group 2: 8 eyes), were included in this retrospective study. All eyes underwent one or more TSCPC with the diode laser (Oculight SLX, Iris Medical) with a minimal follow-up of 2 months. Success was defined as intraocular pressure (IOP) between 6 and 20 mmHg after one or more procedures, with no increase in medical hypotensive therapy, and no progression to another hypotensive procedure.
Mean baseline IOP was 29.4 +/- 7.8 mmHg (range 25 to 60 mmHg) and mean follow-up was 10.3 +/- 6.9 months (range 2 to 26 months). Success rates evaluated at 6 and 12 months (Kaplan Meier survival curves) were 54.4% and 27.7% respectively, with one-third of the eyes retreated once or more. These success rates were similar in both groups with a mean baseline IOP decrease of 38.9 +/- 15.9%. Postoperative uncontrolled hypertony occurred in the first 3 months in 6 (21.4%) eyes, leading to surgical IOP management. Other complications were decrease in visual acuity (14.3%), inflammation (25.5%) and phthisis (3.5%).
TSCPC with the diode laser is a disappointing procedure for the management of refractory pediatric glaucoma, with poor mid-term IOP control and high incidence of complications including severe uncontrolled IOP increase. For these reasons, this cyclodestructive procedure should be considered as a last resort therapy for patients with refractory pediatric glaucoma.
评估接触式二极管经巩膜睫状体光凝术(TSCPC)治疗儿童难治性青光眼的成功率。
本回顾性研究纳入了28例患者的28只眼(年龄范围5个月至26岁),这些患者因原发性先天性青光眼(第1组,20只眼)或无晶状体性先天性青光眼(第2组:8只眼)导致药物和手术治疗无效的儿童青光眼。所有眼睛均接受了一次或多次使用二极管激光(Oculight SLX,Iris Medical)的TSCPC,随访时间最短为2个月。成功定义为在一次或多次手术后眼压(IOP)在6至20 mmHg之间,药物降压治疗无增加,且未进展至另一种降压手术。
平均基线眼压为29.4±7.8 mmHg(范围25至60 mmHg),平均随访时间为10.3±6.9个月(范围2至26个月)。在6个月和12个月时评估的成功率(Kaplan Meier生存曲线)分别为54.4%和27.7%,三分之一的眼睛接受了一次或多次再次治疗。两组的这些成功率相似,平均基线眼压降低了38.9±15.9%。6只眼(21.4%)在术后前3个月出现未控制的高眼压,导致进行手术眼压管理。其他并发症包括视力下降(14.3%)、炎症(25.5%)和眼球痨(3.5%)。
二极管激光TSCPC治疗儿童难治性青光眼是一种令人失望的方法,中期眼压控制不佳,并发症发生率高,包括严重的未控制眼压升高。由于这些原因,这种睫状体破坏手术应被视为儿童难治性青光眼患者的最后手段治疗方法。