Walker I D, Davidson J F, Young P, Conkie J A
Thromb Diath Haemorrh. 1975 Sep 30;34(1):236-45.
Six anabolic steroids were assessed for their ability to enhance plasma fibrinolytic activity in males with ischaemic heart disease. Five 17alpha-alkylated steroids (Ethyloestrenol, Norethandrolone, Methandienone, Methylandrostenediol and Oxymetholone) were examined and all produced a significant increase in plasma plasminogen activator as measured by the euglobulin lysis time. The only non-17alpha-alkylated steroid studied (Methenolone acetate) failed to enhance fibrinolysis. The 17alpha-alkylated steroids studied all deserve more detailed evaluation of their long term effects on plasma fibrinolytic activity.
对六种合成代谢类固醇进行了评估，以研究其增强缺血性心脏病男性血浆纤维蛋白溶解活性的能力。研究了五种17α-烷基化类固醇（乙基雌烯醇、诺乙雄龙、美雄酮、甲基雄烯二醇和羟甲烯龙），通过优球蛋白溶解时间测定，所有这些类固醇均使血浆纤溶酶原激活剂显著增加。唯一研究的非17α-烷基化类固醇（乙酸美替诺龙）未能增强纤维蛋白溶解作用。所研究的17α-烷基化类固醇均值得对其对血浆纤维蛋白溶解活性的长期影响进行更详细的评估。
