Tsukui S, Kanda T, Nara M, Nishino M, Kondo T, Kobayashi I
Department of Laboratory Medicine, Gunma University School of Medicine, Maebashi, Japan.
Int J Obes Relat Metab Disord. 2000 Sep;24(9):1207-11. doi: 10.1038/sj.ijo.0801373.
To evaluate the effects of moderate-intensity regular exercise on serum levels of tumor necrosis factor-alpha (TNF-alpha) and glucose and lipid metabolism parameters.
Longitudinal intervention study of a 5 month exercise training program (30-45 min/day, 4-5 days/week).
Forty-one healthy Japanese women aged 41-69 y at baseline; 27 participants in the exercise program.
Body mass index (BMI), waist-to-hip ratio (WHR), percentage body fat, and fasting levels for serum TNF-alpha, serum soluble TNF receptor p55 (TNF-RI) and TNF receptor p75 (TNF-RII), serum lipids, HbA1c, and serum insulin before and after exercise.
In overweight to obese subjects, serum levels of TNF-alpha, TNF-RI and TNF-RII were significantly higher than those in lean subjects. There were significant correlations between log serum TNF-alpha and BMI, percentage body fat, WHR, HbA1c and log insulin. TNF-RI was significantly correlated with BMI, percentage body fat, WHR and HbA1c. TNF-RII was also associated with BMI, percentage body fat and WHR. However, the correlation between TNF-RII and HbA1c did not reach statistical significance. Neither TNF-RI nor TNF-RII was correlated with log insulin. In contrast, TNF-alpha, TNF-RI and TNF-RII were negatively correlated with HDL cholesterol. Regular exercise decreased BMI, percentage body fat, HbA1c, serum TNF-alpha, TNF-RI and TNF-RII and increased HDL cholesterol levels. In addition, exercise-induced change in serum TNF-alpha was independently correlated with changes in HbA1c and serum insulin, after being adjusted for the change in fat-free mass.
Changes in serum TNF-alpha that occur with exercise may play an important role in improving glucose metabolism parameters.
评估中等强度规律运动对血清肿瘤坏死因子-α（TNF-α）水平及糖脂代谢参数的影响。
一项为期5个月运动训练计划（每天30 - 45分钟，每周4 - 5天）的纵向干预研究。
41名基线年龄为41 - 69岁的健康日本女性；27名参与运动计划。
运动前后的体重指数（BMI）、腰臀比（WHR）、体脂百分比，以及血清TNF-α、血清可溶性TNF受体p55（TNF-RI）和TNF受体p75（TNF-RII）的空腹水平、血脂、糖化血红蛋白（HbA1c）和血清胰岛素。
超重至肥胖受试者的血清TNF-α、TNF-RI和TNF-RII水平显著高于瘦受试者。血清TNF-α对数与BMI、体脂百分比、WHR、HbA1c和胰岛素对数之间存在显著相关性。TNF-RI与BMI、体脂百分比、WHR和HbA1c显著相关。TNF-RII也与BMI、体脂百分比和WHR相关。然而，TNF-RII与HbA1c之间的相关性未达到统计学意义。TNF-RI和TNF-RII均与胰岛素对数无相关性。相反，TNF-α、TNF-RI和TNF-RII与高密度脂蛋白胆固醇呈负相关。规律运动降低了BMI、体脂百分比、HbA1c、血清TNF-α、TNF-RI和TNF-RII，并提高了高密度脂蛋白胆固醇水平。此外，在调整无脂肪体重变化后，运动引起的血清TNF-α变化与HbA1c和血清胰岛素变化独立相关。
运动引起的血清TNF-α变化可能在改善糖代谢参数中起重要作用。
