下丘脑手术隔离对其神经递质含量的影响。
Effect of surgical isolation of the hypothalamus on its neurotransmitter content.
作者信息
Brownstein M J, Palkovits M, Tappaz M L, Saavedra J M, Kizer J S
出版信息
Brain Res. 1976 Nov 26;117(2):287-95. doi: 10.1016/0006-8993(76)90736-8.
The concentrations of norepinephrine, dopamine-beta-hydroxylase, dopamine, tyrosine hydroxylase, phenylethanolamine-N-methyltransferase, serotonin, tryptophan hydroxylase, histamine, glutamic acid decarboxylase, and choline acetyltransferase were determined in selected hypothalamic nuclei and in the median eminence after deafferentation of the medial basal hypothalamus. Norepinephrine and dopamine-beta-hydroxylase fell markedly while dopamine and tyrosine hydroxylase did not. Serotonin also decreased in all regions studied; histamine decreased in none. Choline acetyltransferase, phenylethanolamine-N-methyltransferase, and glutamic acid decarboxylase declined in some areas, but not in others.
在内侧基底下丘脑传入神经切断后，测定了所选下丘脑核团及正中隆起中去甲肾上腺素、多巴胺-β-羟化酶、多巴胺、酪氨酸羟化酶、苯乙醇胺-N-甲基转移酶、5-羟色胺、色氨酸羟化酶、组胺、谷氨酸脱羧酶和胆碱乙酰转移酶的浓度。去甲肾上腺素和多巴胺-β-羟化酶显著下降，而多巴胺和酪氨酸羟化酶则未下降。在所研究的所有区域中5-羟色胺也减少；组胺在任何区域均未减少。胆碱乙酰转移酶、苯乙醇胺-N-甲基转移酶和谷氨酸脱羧酶在某些区域下降，但在其他区域未下降。
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