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大鼠视网膜和下丘脑后部中苯乙醇胺-N-甲基转移酶阳性/酪氨酸羟化酶阴性神经元的免疫组织化学证据

Immunohistochemical evidence for phenylethanolamine-N-methyltransferase-positive/tyrosine hydroxylase-negative neurones in the retina and the posterior hypothalamus of the rat.

作者信息

Foster G A, Hökfelt T, Coyle J T, Goldstein M

出版信息

Brain Res. 1985 Mar 18;330(1):183-8. doi: 10.1016/0006-8993(85)90025-3.

DOI:10.1016/0006-8993(85)90025-3
PMID:2859084
Abstract

Phenylethanolamine-N-methyltransferase (PNMT)-immunoreactive neurons were observed in the inner nuclear layer of the rat retina, apparently giving rise to fiber networks mainly in layer 3 of the inner plexiform layer. These neurons did not seem to contain tyrosine hydroxylase (TH)-like or dopamine-beta-hydroxylase (DBH)-like immunoreactivity and were much smaller and more numerous than the previously described TH-positive dopamine neurons. PNMT-positive, but TH- and DBH-negative neurons were also observed in small numbers in the basal posterior hypothalamus.

摘要

在大鼠视网膜内核层观察到苯乙醇胺 -N-甲基转移酶(PNMT)免疫反应性神经元,这些神经元显然主要在内网状层第3层形成纤维网络。这些神经元似乎不含有酪氨酸羟化酶(TH)样或多巴胺β-羟化酶(DBH)样免疫反应性,并且比先前描述的TH阳性多巴胺能神经元小得多且数量更多。在基底后下丘脑也少量观察到PNMT阳性但TH和DBH阴性的神经元。

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