Sprott H, Rzanny R, Reichenbach J R, Kaiser W A, Hein G, Stein G
Department of Rheumatology and Institute of Physical Medicine, University Hospital Zürich, Switzerland.
Rheumatology (Oxford). 2000 Oct;39(10):1121-5. doi: 10.1093/rheumatology/39.10.1121.
To measure inorganic phosphate (Pi), phosphocreatine (PCr), ATP and phosphodiesters (PDE) in fibromyalgic muscle tissue by (31)P magnetic resonance spectroscopy.
A 1.5 Tesla scanner with a P 100 surface coil was used to examine 15 patients (mean age 49.9+/-14.3 yr) with fibromyalgia, according to the American College of Rheumatology criteria, and 17 healthy controls (mean age 30.2+/-5.8 yr).
Compared with the controls, there were increases in the levels of PDE (+22%, P = 0.032) and Pi (+19%, P = 0.019) in the spectra of fibromyalgia patients, but there was no difference in pH.
The metabolic differences we found may have been related to weakness and fatigue in the fibromyalgia patients, but they do not fully explain the fibromyalgia symptoms.
通过磷-31磁共振波谱法测量纤维肌痛肌肉组织中的无机磷酸盐（Pi）、磷酸肌酸（PCr）、三磷酸腺苷（ATP）和磷酸二酯（PDE）。
使用配备P 100表面线圈的1.5特斯拉扫描仪，根据美国风湿病学会标准，对15名纤维肌痛患者（平均年龄49.9±14.3岁）和17名健康对照者（平均年龄30.2±5.8岁）进行检查。
与对照组相比，纤维肌痛患者的光谱中PDE水平升高（+22%，P = 0.032），Pi水平升高（+19%，P = 0.019），但pH值无差异。
我们发现的代谢差异可能与纤维肌痛患者的虚弱和疲劳有关，但它们并不能完全解释纤维肌痛症状。
