Brown T R, Stoyanova R, Greenberg T, Srinivasan R, Murphy-Boesch J
Fox Chase Cancer Center, Department of NMR and Medical Spectroscopy, Philadelphia, Pennsylvania 19111, USA.
Magn Reson Med. 1995 Mar;33(3):417-21. doi: 10.1002/mrm.1910330316.
Nuclear Overhauser effect (NOE) enhancements and relaxation times of 31P metabolites in human calf were measured in 12 volunteers (4 men and 8 women) at 1.5 T using a dual tuned four-ring birdcage. The NOE enhancements of inorganic phosphate (Pi), phosphocreatine (PCr), gamma-, alpha-, and beta-nucleoside triphosphate (NTP) from 19 measurements were 0.51 +/- 0.10, 0.64 +/- 0.03, 0.53 +/- 0.03, 0.56 +/- 0.08, and 0.47 +/- 0.05, respectively. The relaxation times were independent of proton irradiation and from 23 measurements were 3.49 +/- 0.35, 4.97 +/- 0.58, 4.07 +/- 0.36, 2.90 +/- 0.25, and 3.61 +/- 0.25 s for Pi, PCr, gamma-, alpha-, and beta-NTP, respectively. No significant differences between gender and age were observed for either NOE enhancements or relaxation times. Also, among nine volunteers, we observed no significant differences in T1 between the coupled and decoupled cases.
在1.5T磁场下，使用双调谐四环鸟笼线圈对12名志愿者（4名男性和8名女性）人小腿中的31P代谢物的核Overhauser效应（NOE）增强和弛豫时间进行了测量。19次测量中，无机磷酸盐（Pi）、磷酸肌酸（PCr）、γ-、α-和β-核苷三磷酸（NTP）的NOE增强分别为0.51±0.10、0.64±0.03、0.53±0.03、0.56±0.08和0.47±0.05。弛豫时间与质子照射无关，23次测量中，Pi、PCr、γ-、α-和β-NTP的弛豫时间分别为3.49±0.35、4.97±0.58、4.07±0.36、2.90±0.25和3.61±0.25秒。在NOE增强或弛豫时间方面，未观察到性别和年龄之间的显著差异。此外，在9名志愿者中，我们观察到耦合和去耦合情况下T1无显著差异。
