Rietveld M J, van Der Valk J C, Bongers I L, Stroet T M, Slagboom P E, Boomsma D I
Vrije Universiteit, Department of Biological Psychology, Amsterdam.
Twin Res. 2000 Sep;3(3):134-41. doi: 10.1375/136905200320565409.
This study reports on zygosity determination in twins of childhood age. Parents responded to questionnaire items dealing with twin similarity in physical characteristics and frequency of mistaking one twin for another by parents, relatives and strangers. The accuracy of zygosity diagnosis was evaluated across twins aged 6, 8, and 10 and across parents. In addition, it was examined whether the use of multiple raters and the use of longitudinal data lead to an improvement of zygosity assignment. Complete data on zygosity questions and on genetic markers or blood profiles were available for 618 twin pairs at the age of 6 years. The method used was predictive discriminant analyses. Agreement between zygosity assigned by the replies to the questions and zygosity determined by DNA markers/blood typing was around 93%. The accuracy of assignment remained constant across age and parents. Analyses of data provided by both parents and collected over multiple ages did not result in better prediction of zygosity. Details on the discriminant function are provided.
本研究报告了儿童期双胞胎的合子性判定情况。父母们对问卷项目做出了回应，这些项目涉及双胞胎在身体特征上的相似性以及父母、亲属和陌生人将一个双胞胎误认成另一个的频率。对6岁、8岁和10岁的双胞胎以及他们的父母进行了合子性诊断准确性的评估。此外，还研究了使用多个评估者以及使用纵向数据是否会提高合子性判定的准确性。在6岁时，有618对双胞胎对合子性问题以及基因标记或血型数据完整。所采用的方法是预测判别分析。通过对问题的回答所确定的合子性与通过DNA标记/血型确定的合子性之间的一致性约为93%。合子性判定的准确性在不同年龄和父母群体中保持不变。对父母双方提供的、在多个年龄段收集的数据进行分析，并没有带来更好的合子性预测效果。文中提供了判别函数的详细信息。
