Sheyn I, Mira J L, Blanco R, Walton M B, Husseinzadeh N
Departments of Pathology, Texas Tech University Health Science Center, Lubbock, TX 79430, USA.
Arch Pathol Lab Med. 2000 Oct;124(10):1539-41. doi: 10.5858/2000-124-1539-CWDAAL.
We describe a case of a concomitant well-differentiated endometrial endometrioid adenocarcinoma and leiomyosarcoma of the uterus in a 66-year-old woman who presented with a 6-month history of vaginal bleeding. The patient underwent total hysterectomy for endometrial carcinoma diagnosed by endometrial biopsy. Gross examination of the specimen revealed an endometrial mass bulging into the endometrial cavity and an underlying well-circumscribed nodule separated from the endometrial mass by a myometrial band. Frozen section performed at the time of the total hysterectomy rendered a diagnosis of malignant mixed-müllerian tumor. Histologic examination of the permanent sections revealed well-differentiated endometrial endometrioid adenocarcinoma clearly separated from a high-grade leiomyosarcoma. Differential diagnosis included malignant mixed-müllerian tumor. However, no admixture of carcinomatous and sarcomatous elements was present. There were no heterologous elements. To the best of our knowledge, no similar case has been described in the English literature.
我们描述了一例66岁女性患者，其患有子宫高分化子宫内膜样腺癌和平滑肌肉瘤，伴有6个月的阴道出血病史。患者因子宫内膜活检诊断为子宫内膜癌而接受了全子宫切除术。标本的大体检查显示，一个子宫内膜肿物突入子宫内膜腔，其下方有一个边界清楚的结节，该结节与子宫内膜肿物之间被一条肌层带分隔。全子宫切除时进行的冰冻切片诊断为恶性混合性苗勒管肿瘤。永久切片的组织学检查显示，高分化子宫内膜样腺癌与高级别平滑肌肉瘤明显分离。鉴别诊断包括恶性混合性苗勒管肿瘤。然而，未发现癌性和肉瘤性成分的混合。也没有异源性成分。据我们所知，英文文献中尚未描述过类似病例。
