van Hemert J C
Acta Psychiatr Scand. 1975 Oct;52(4):237-45. doi: 10.1111/j.1600-0447.1975.tb00039.x.
A 6-week double-blind cross-over study comparing pipamperone with placebo was conducted in 20 female mental retardates with behavioural disorders. The ages of the patients ranged between 22 and 42 years. After a 2-week washout period, patients were randomly allocated to either pipamperone or placebo treatment. The initial dosage of pipamperone was 40 mg b.i.d., which was gradually increased to 80 mg b.i.d. within 5 days. Patients were assessed using a ten-item rating scale before and after each week of treatment. For six of the ten items, patients showed a better response during the pipamperone than during the placebo period. When pre-trial scores were compared with those at the end of the trial, seven items had significantly improved with pipamperone. The nursing staff considered the patients more alert and amenable during pipamperone treatment.
对20名患有行为障碍的女性智力迟钝患者进行了一项为期6周的双盲交叉研究，比较了匹哌氮芥与安慰剂的效果。患者年龄在22岁至42岁之间。经过2周的洗脱期后，患者被随机分配接受匹哌氮芥或安慰剂治疗。匹哌氮芥的初始剂量为每日两次，每次40毫克，在5天内逐渐增加至每日两次，每次80毫克。在治疗的每周前后，使用十项评分量表对患者进行评估。在十项中的六项上，患者在服用匹哌氮芥期间的反应比服用安慰剂期间更好。将试验前的分数与试验结束时的分数进行比较时，使用匹哌氮芥治疗的七项有显著改善。护理人员认为患者在服用匹哌氮芥治疗期间更加警觉且易于管理。
