黄霉素和万古霉素对耐万古霉素质粒接合转移的影响。
Impact of flavophospholipol and vancomycin on conjugational transfer of vancomycin resistance plasmids.
作者信息
Riedl S, Ohlsen K, Werner G, Witte W, Hacker J
机构信息
Institute for Molecular Biology of Infectious Diseases, The University of Würzburg, D-97070 Würzburg, Germany.
出版信息
Antimicrob Agents Chemother. 2000 Nov;44(11):3189-92. doi: 10.1128/AAC.44.11.3189-3192.2000.
Abstract
The influence of vancomycin and flavophospholipol (FPL) on the transfer rate of conjugative plasmids harboring the vancomycin resistance operon vanA was determined in several clinical and animal isolates of Enterococcus faecium. FPL significantly inhibited the frequency of transfer of conjugative VanA plasmids up to 70-fold. Vancomycin had no significant effect on the transfer rate of VanA plasmids.
摘要
在几种粪肠球菌临床和动物分离株中，测定了万古霉素和黄霉素（FPL）对携带万古霉素抗性操纵子vanA的接合质粒转移率的影响。FPL可显著抑制接合型VanA质粒的转移频率，最高可达70倍。万古霉素对VanA质粒的转移率无显著影响。
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