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化脓性链球菌临床分离株对多种氟喹诺酮类药物的耐药性：gyrA和parC的鉴定以及与耐药相关的点突变特征分析

Resistance to multiple fluoroquinolones in a clinical isolate of Streptococcus pyogenes: identification of gyrA and parC and specification of point mutations associated with resistance.

作者信息

Yan S S, Fox M L, Holland S M, Stock F, Gill V J, Fedorko D P

机构信息

Microbiology Service, CPD, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1508, USA.

出版信息

Antimicrob Agents Chemother. 2000 Nov;44(11):3196-8. doi: 10.1128/AAC.44.11.3196-3198.2000.

DOI:10.1128/AAC.44.11.3196-3198.2000
PMID:11036052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC101632/
Abstract

A strain of Streptococcus pyogenes resistant to multiple fluoroquinolones was isolated from the blood of an immunocompromised patient. Resistance to fluoroquinolones in S. pyogenes has not been previously studied. Compared to 10 sensitive strains of S. pyogenes, the fluoroquinolone-resistant clinical isolate of S. pyogenes presented point mutations in gyrA, predicting that serine-81 was changed to phenylalanine and that methionine-99 was changed to leucine, and in parC, predicting that serine-79 was changed to tyrosine. The mechanism of fluoroquinolone resistance in this isolate of S. pyogenes appears to be analogous to previously reported mechanisms for Streptococcus pneumoniae.

摘要

从一名免疫功能低下患者的血液中分离出一株对多种氟喹诺酮耐药的化脓性链球菌。此前尚未对化脓性链球菌对氟喹诺酮的耐药性进行过研究。与10株化脓性链球菌敏感菌株相比，该氟喹诺酮耐药的化脓性链球菌临床分离株在gyrA基因出现点突变，预测丝氨酸81变为苯丙氨酸，甲硫氨酸99变为亮氨酸，在parC基因也出现点突变，预测丝氨酸79变为酪氨酸。该化脓性链球菌分离株中氟喹诺酮耐药机制似乎与先前报道的肺炎链球菌耐药机制类似。

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