• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

幽门螺杆菌四环素耐药临床分离株的分离与鉴定

Isolation and characterization of tetracycline-resistant clinical isolates of Helicobacter pylori.

作者信息

Kwon D H, Kim J J, Lee M, Yamaoka Y, Kato M, Osato M S, El-Zaatari F A, Graham D Y

机构信息

Department of Medicine, Baylor College of Medicine, and Veterans Affairs Medical Center, Houston, Texas 77030, USA.

出版信息

Antimicrob Agents Chemother. 2000 Nov;44(11):3203-5. doi: 10.1128/AAC.44.11.3203-3205.2000.

DOI:10.1128/AAC.44.11.3203-3205.2000
PMID:11036054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC101634/
Abstract

Tetracycline is an important component of combination therapies for Helicobacter pylori eradication. Twenty-nine tetracycline-resistant isolates requiring MICs ranging from 4 to 16 microgram/ml were isolated from Korean (22 of 460) and Japanese (7 of 105) patients. Interestingly, all of the 29 tetracycline-resistant isolates exhibited cross-resistance to metronidazole, and the cross-resistance was transferred to tetracycline-sensitive H. pylori strains.

摘要

四环素是根除幽门螺杆菌联合疗法的重要组成部分。从韩国患者（460例中的22例）和日本患者（105例中的7例）中分离出29株四环素耐药菌株，其最低抑菌浓度（MIC）范围为4至16微克/毫升。有趣的是，所有29株四环素耐药菌株均对甲硝唑表现出交叉耐药性，且这种交叉耐药性可转移至四环素敏感的幽门螺杆菌菌株。

相似文献

1
Isolation and characterization of tetracycline-resistant clinical isolates of Helicobacter pylori.幽门螺杆菌四环素耐药临床分离株的分离与鉴定
Antimicrob Agents Chemother. 2000 Nov;44(11):3203-5. doi: 10.1128/AAC.44.11.3203-3205.2000.
2
Increase in resistance rates of H. pylori isolates to metronidazole and tetracycline--comparison of three 3-year studies.幽门螺杆菌分离株对甲硝唑和四环素耐药率的增加——三项为期 3 年的研究比较。
Arch Iran Med. 2010 May;13(3):177-87.
3
Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea.韩国幽门螺杆菌分离株对甲硝唑、克拉霉素和四环素的耐药性分析。
J Antimicrob Chemother. 2001 Apr;47(4):459-61. doi: 10.1093/jac/47.4.459.
4
An increase in Helicobacter pylori strains resistant to metronidazole: a five-year study.幽门螺杆菌对甲硝唑耐药菌株的增加：一项为期五年的研究。
Helicobacter. 1996 Mar;1(1):57-61. doi: 10.1111/j.1523-5378.1996.tb00009.x.
5
[Prevalence of metronidazole, clarithromycin and tetracycline resistance in Helicobacter pylori isolated from Chilean patients].[从智利患者分离出的幽门螺杆菌对甲硝唑、克拉霉素和四环素的耐药率]
Rev Med Chil. 2007 Mar;135(3):287-93. doi: 10.4067/s0034-98872007000300002. Epub 2007 Apr 26.
6
Prevalence of Helicobacter pylori resistance to metronidazole, clarithromycin, amoxycillin, tetracycline and trovafloxacin in The Netherlands.荷兰幽门螺杆菌对甲硝唑、克拉霉素、阿莫西林、四环素和曲伐沙星的耐药率
J Antimicrob Chemother. 1999 Apr;43(4):511-5. doi: 10.1093/jac/43.4.511.
7
Evolution of metronidazole and tetracycline susceptibility pattern in Helicobacter pylori at a hospital in Saudi Arabia.沙特阿拉伯一家医院幽门螺杆菌对甲硝唑和四环素敏感性模式的演变
Int J Antimicrob Agents. 2001 Mar;17(3):233-6. doi: 10.1016/s0924-8579(00)00336-8.
8
Antimicrobial resistance of Helicobacter pylori in Poland: a multicentre study.波兰幽门螺杆菌的抗菌药物耐药性：一项多中心研究。
Int J Antimicrob Agents. 2005 Sep;26(3):230-4. doi: 10.1016/j.ijantimicag.2005.06.015.
9
Resistance rate to antibiotics of Helicobacter pylori isolates in eastern Taiwan.台湾东部幽门螺杆菌分离株的抗生素耐药率。
J Gastroenterol Hepatol. 2007 May;22(5):720-3. doi: 10.1111/j.1440-1746.2006.04743.x.
10
Antimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey.土耳其西北部幽门螺杆菌菌株对包括左氧氟沙星在内的五种抗生素的耐药性。
Rev Soc Bras Med Trop. 2015 May-Jun;48(3):278-84. doi: 10.1590/0037-8682-0027-2015.

引用本文的文献

1
Anti-Helicobacter pylori potential of artemisinin and its derivatives.青蒿素及其衍生物的抗幽门螺杆菌潜力。
Antimicrob Agents Chemother. 2012 Sep;56(9):4594-607. doi: 10.1128/AAC.00407-12. Epub 2012 Jun 11.
2
Absence of Helicobacter pylori high tetracycline resistant 16S rDNA AGA926-928TTC genotype in gastric biopsy specimens from dyspeptic patients of a city in the interior of São Paulo, Brazil.巴西圣保罗内陆城市消化不良患者胃活检标本中幽门螺杆菌高四环素耐药 16S rDNA AGA926-928TTC 基因型缺失。
BMC Gastroenterol. 2012 May 17;12:49. doi: 10.1186/1471-230X-12-49.
3
Who's Winning the War? Molecular Mechanisms of Antibiotic Resistance in Helicobacter pylori.谁将赢得这场战争？幽门螺杆菌抗生素耐药性的分子机制
Curr Drug ther. 2008 Sep 1;3(3):190-203. doi: 10.2174/157488508785747899.
4
Antibiotic resistance of Helicobacter pylori from patients in Ile-Ife, South-west, Nigeria.尼日利亚西南部伊莱-伊费地区患者幽门螺杆菌的抗生素耐药性
Afr Health Sci. 2007 Sep;7(3):143-7. doi: 10.5555/afhs.2007.7.3.143.
5
Antibiotic susceptibility of Helicobacter pylori clinical isolates: comparative evaluation of disk-diffusion and E-test methods.幽门螺杆菌临床分离株的抗生素敏感性：纸片扩散法和E-test法的比较评估
Curr Microbiol. 2006 Oct;53(4):329-34. doi: 10.1007/s00284-006-0143-1. Epub 2006 Sep 12.
6
Bactericidal and morphological effects of NE-2001, a novel synthetic agent directed against Helicobacter pylori.新型合成药物NE-2001对幽门螺杆菌的杀菌及形态学作用
Antimicrob Agents Chemother. 2005 Aug;49(8):3468-73. doi: 10.1128/AAC.49.8.3468-3473.2005.
7
16S rRNA mutations that confer tetracycline resistance in Helicobacter pylori decrease drug binding in Escherichia coli ribosomes.幽门螺杆菌中赋予四环素抗性的16S rRNA突变会降低药物在大肠杆菌核糖体中的结合。
J Bacteriol. 2005 Jun;187(11):3708-12. doi: 10.1128/JB.187.11.3708-3712.2005.
8
High eradication rates of Helicobacter pylori infection with first- and second-line combination of esomeprazole, tetracycline, and metronidazole in patients allergic to penicillin.对青霉素过敏患者使用埃索美拉唑、四环素和甲硝唑的一线及二线联合用药方案治疗幽门螺杆菌感染的根除率较高。
Dig Dis Sci. 2005 Apr;50(4):634-9. doi: 10.1007/s10620-005-2549-1.
9
Tetracycline-resistant clinical Helicobacter pylori isolates with and without mutations in 16S rRNA-encoding genes.对四环素耐药的临床幽门螺杆菌分离株，其16S rRNA编码基因有无突变。
Antimicrob Agents Chemother. 2005 Feb;49(2):578-83. doi: 10.1128/AAC.49.2.578-583.2005.
10
Laboratory diagnosis and susceptibility profile of Helicobacter pylori infection in the Philippines.菲律宾幽门螺杆菌感染的实验室诊断与药敏谱
Ann Clin Microbiol Antimicrob. 2004 Nov 16;3:25. doi: 10.1186/1476-0711-3-25.

本文引用的文献

1
Analysis of rdxA and involvement of additional genes encoding NAD(P)H flavin oxidoreductase (FrxA) and ferredoxin-like protein (FdxB) in metronidazole resistance of Helicobacter pylori.幽门螺杆菌中rdxA的分析以及编码NAD(P)H黄素氧化还原酶（FrxA）和铁氧化还原蛋白样蛋白（FdxB）的其他基因在甲硝唑耐药性中的作用。
Antimicrob Agents Chemother. 2000 Aug;44(8):2133-42. doi: 10.1128/AAC.44.8.2133-2142.2000.
2
Primary and combined resistance to four antimicrobial agents in Helicobacter pylori in Sofia, Bulgaria.保加利亚索非亚幽门螺杆菌对四种抗菌药物的原发性和联合耐药性
J Med Microbiol. 2000 May;49(5):415-418. doi: 10.1099/0022-1317-49-5-415.
3
Antimicrobial susceptibility testing of Helicobacter pylori in a large multicenter trial: the MACH 2 study.一项大型多中心试验中幽门螺杆菌的药敏试验：MACH 2研究
Antimicrob Agents Chemother. 1999 Nov;43(11):2747-52. doi: 10.1128/AAC.43.11.2747.
4
Metronidazole and clarithromycin resistance amongst Helicobacter pylori isolates from a large metropolitan hospital in the United States.美国一家大型都市医院分离出的幽门螺杆菌菌株对甲硝唑和克拉霉素的耐药性。
Int J Antimicrob Agents. 1999 Aug;12(4):341-7. doi: 10.1016/s0924-8579(99)00079-5.
5
Stable and unstable amoxicillin resistance in Helicobacter pylori: should antibiotic resistance testing be performed prior to eradication therapy?幽门螺杆菌中阿莫西林耐药的稳定性与不稳定性：根除治疗前是否应进行抗生素耐药性检测？
J Clin Microbiol. 1999 Aug;37(8):2740-1. doi: 10.1128/JCM.37.8.2740-2741.1999.
6
Lymphoma of the gastrointestinal tract.胃肠道淋巴瘤
Semin Oncol. 1999 Jun;26(3):324-37.
7
Helicobacter pylori: the size of the problem.幽门螺杆菌：问题的严重程度
Gut. 1998 Jul;43 Suppl 1(Suppl 1):S6-9. doi: 10.1136/gut.43.2008.s6.
8
Helicobacter pylori.幽门螺杆菌
Infect Dis Clin North Am. 1998 Mar;12(1):185-97. doi: 10.1016/s0891-5520(05)70417-7.
9
Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution.四环素抗性决定因素：作用机制、表达调控、遗传流动性及分布
FEMS Microbiol Rev. 1996 Oct;19(1):1-24. doi: 10.1111/j.1574-6976.1996.tb00251.x.
10
Multidrug efflux pumps of gram-negative bacteria.革兰氏阴性菌的多药外排泵
J Bacteriol. 1996 Oct;178(20):5853-9. doi: 10.1128/jb.178.20.5853-5859.1996.