幽门螺杆菌四环素耐药临床分离株的分离与鉴定
Isolation and characterization of tetracycline-resistant clinical isolates of Helicobacter pylori.
作者信息
Kwon D H, Kim J J, Lee M, Yamaoka Y, Kato M, Osato M S, El-Zaatari F A, Graham D Y
机构信息
Department of Medicine, Baylor College of Medicine, and Veterans Affairs Medical Center, Houston, Texas 77030, USA.
出版信息
Antimicrob Agents Chemother. 2000 Nov;44(11):3203-5. doi: 10.1128/AAC.44.11.3203-3205.2000.
Abstract
Tetracycline is an important component of combination therapies for Helicobacter pylori eradication. Twenty-nine tetracycline-resistant isolates requiring MICs ranging from 4 to 16 microgram/ml were isolated from Korean (22 of 460) and Japanese (7 of 105) patients. Interestingly, all of the 29 tetracycline-resistant isolates exhibited cross-resistance to metronidazole, and the cross-resistance was transferred to tetracycline-sensitive H. pylori strains.
摘要
四环素是根除幽门螺杆菌联合疗法的重要组成部分。从韩国患者（460例中的22例）和日本患者（105例中的7例）中分离出29株四环素耐药菌株，其最低抑菌浓度（MIC）范围为4至16微克/毫升。有趣的是，所有29株四环素耐药菌株均对甲硝唑表现出交叉耐药性，且这种交叉耐药性可转移至四环素敏感的幽门螺杆菌菌株。
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