Maddox R R, Rush D R, Rapp R P, Foster T S, Mazella V, McKean H E
Am J Hosp Pharm. 1977 Jan;34(1):29-34.
Methods which might be useful in preventing cephalothin-induced phlebitis following intravenous administration of the buffered drug were investigated. One hundred and twenty adult orthopedic patients were assigned randomly to either a control group or one of five treatment groups. The treatment regimens studied were: addition of hydrocortisone phosphate 10 mg to each liter of intravenous fluid; addition of heparin 1,000 units to each liter of intravenous fluid; addition of heparin 500 units and hydrocortisone phosphate 1 mg to each liter of intravenous fluid; addition of heparin 1,000 units and hydrocortisone phosphate 10 mg to each liter of intravenous fluid; and filtration of intravenous solutions through a 0.22-mum inline filter. All patients in the study received intravenous buffered cephalothin at a dosage of 1 g every six hours for a minimum of 48 hours. Phlebitis was assessed every 12 hours according to predetermined criteria. Significant differences were found in the incidence of phlebitis at 48 hours between the control group and the last three study groups (see above). It is concluded that postinfusion phlebitis following cephalothin administration can be reduced by the concomitant addition of heparin and hydrocortisone to the intravenous solution or by the use of an inline 0.22-mum final filter.
研究了在静脉注射缓冲药物后预防头孢噻吩引起的静脉炎可能有用的方法。120名成年骨科患者被随机分为对照组或五个治疗组之一。所研究的治疗方案为：每升静脉输液中添加10毫克磷酸氢化可的松；每升静脉输液中添加1000单位肝素；每升静脉输液中添加500单位肝素和1毫克磷酸氢化可的松；每升静脉输液中添加1000单位肝素和10毫克磷酸氢化可的松；以及通过0.22微米在线过滤器过滤静脉溶液。研究中的所有患者均接受静脉注射缓冲头孢噻吩，剂量为每6小时1克，至少持续48小时。根据预定标准每12小时评估一次静脉炎。在对照组与最后三个研究组之间，48小时时静脉炎的发生率存在显著差异（见上文）。得出的结论是，在静脉溶液中同时添加肝素和氢化可的松或使用0.22微米在线终端过滤器可降低头孢噻吩给药后的输注后静脉炎。
