Holmström M
Oronkliniken, Akademiska sjukhuset, Uppsala.
Lakartidningen. 2000 Aug 23;97(34):3611-5.
Nasal polyposis, a disease seen mainly in humans and dominated in most cases by an eosinophilic inflammation of unknown etiology, has been an enigma for a few thousand years. Polyps are, however, overrepresented in patients with general airway inflammation as seen in asthma and idiopathic rhinitis, and in patients with infective nasal disease of chronic origin as seen in cystic fibrosis, immune deficiencies and dental sinusitis. Due to the eosinophilic nature of the inflammation, polyps are on the whole sensitive to local steroid treatment with spray or drops. Surgery is indicated when the polyps are solitary or when medical treatment fails.
鼻息肉病主要见于人类,多数情况下以病因不明的嗜酸性粒细胞炎症为主导,几千年来一直是个谜。然而,息肉在患有如哮喘和特发性鼻炎等一般气道炎症的患者中以及在患有如囊性纤维化、免疫缺陷和牙源性鼻窦炎等慢性感染性鼻病的患者中更为常见。由于炎症的嗜酸性粒细胞性质,息肉总体上对喷雾或滴剂的局部类固醇治疗敏感。当息肉为单发或药物治疗失败时,需进行手术治疗。