两个基因组的故事：大肠杆菌和枯草芽孢杆菌中双链染色体的解析

A tale of two genomes: resolution of dimeric chromosomes in Escherichia coli and Bacillus subtilis.

作者信息

Sciochetti S A, Piggot P J

机构信息

Department of Microbiology & Immunology, Temple University School of Medicine, Philadelphia, PA, USA.

出版信息

Res Microbiol. 2000 Sep;151(7):503-11. doi: 10.1016/s0923-2508(00)00220-5.

DOI:10.1016/s0923-2508(00)00220-5

PMID:11037128

Abstract

Dimeric chromosomes can be formed during replication of circular bacterial chromosomes by an odd number of homologous recombination events between sister chromosomes. In the absence of a compensating recombination reaction such dimers cannot be segregated from each other as the cell divides. This review highlights the shared and divergent mechanisms employed by Escherichia coli and Bacillus subtilis in their effort to resolve and partition dimeric chromosomes safely. In particular, we discuss the Xer-type recombinases, RecA, FtsK/SpoIIIE, and dif.

摘要

在环状细菌染色体复制过程中，姐妹染色体之间奇数个同源重组事件可形成二聚体染色体。如果没有补偿性重组反应，随着细胞分裂，此类二聚体无法彼此分离。本综述着重介绍了大肠杆菌和枯草芽孢杆菌为安全解决和分配二聚体染色体所采用的共同及不同机制。特别是，我们讨论了Xer型重组酶、RecA、FtsK/SpoIIIE和dif。