Ascherman J A, Knowles S L, Attkiss K
Department of Surgery, Columbia-Presbyterian Medical Center, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
Ann Plast Surg. 2000 Oct;45(4):438-41. doi: 10.1097/00000637-200045040-00016.
Docetaxel (Taxotere) is a relatively new antineoplastic agent that is proving to be clinically useful in the treatment of a number of major solid tumors, including breast, ovarian, lung, and prostate carcinoma. Common systemic toxicities include neutropenia, alopecia, nausea, and vomiting. The authors report 5 patients (age range, 54-89 years) who experienced extravasation injuries with dramatic clinical presentations during peripheral intravenous administration of docetaxel. The authors did not find any other reported series of docetaxel extravasation in an extensive literature review. They present these 5 patients and provide treatment recommendations.
多西他赛（泰索帝）是一种相对较新的抗肿瘤药物，已证明在治疗多种主要实体瘤（包括乳腺癌、卵巢癌、肺癌和前列腺癌）方面具有临床应用价值。常见的全身毒性包括中性粒细胞减少、脱发、恶心和呕吐。作者报告了5例患者（年龄范围为54 - 89岁），他们在多西他赛外周静脉给药期间发生了外渗损伤，临床表现显著。作者在广泛的文献综述中未发现任何其他关于多西他赛外渗的报道系列。他们介绍了这5例患者并提供了治疗建议。
