del Olmo J A, Pascual I, Bagán J V, Serra M A, Escudero A, Rodriguez F, Rodrigo J M
Service of Hepatology, Hospital Clínico Universitario, Valencia, Spain.
Eur J Oral Sci. 2000 Oct;108(5):378-82. doi: 10.1034/j.1600-0722.2000.108005378.x.
Lichen planus (LP) may represent a mucosal reaction to a variety of factors including hepatitis C virus (HCV) infection. We compared the prevalence of HCV infection in patients with LP of the oral mucosa and chronic liver disease (LP-CLD) with those suffering exclusively from LP or from chronic liver disease (CLD). A total of 267 outpatients participated in a prospective study. There were 41 patients in the LP-CLD group, 128 in the LP group, and 98 in the CLD group. The diagnosis of LP was based on typical macroscopic and histopathologic features and the diagnosis of liver disease on liver histology. Serum samples were screened for anti-HCV antibodies. In 89 patients, serum HCV RNA was also measured. The overall prevalence of anti-HCV antibodies was 29.2% (78/267 patients). Serum HCV RNA levels were positive in 96.2% of anti-HCV-positive patients and in none of anti-HCV-negative subjects. Anti-HCV-positivity was more frequent in the groups of LP-CLD (78%) and CLD (42.8%) than in the LP group (3.1%). It is concluded that HCV infection plays an etiopathogenetic role in CLD associated with oral LP, whereas according to the present findings, the majority of patients suffering exclusively from oral LP are not infected by the HCV.
扁平苔藓（LP）可能是对包括丙型肝炎病毒（HCV）感染在内的多种因素的一种黏膜反应。我们比较了口腔黏膜扁平苔藓合并慢性肝病（LP-CLD）患者、单纯患有扁平苔藓或慢性肝病（CLD）患者中HCV感染的患病率。共有267名门诊患者参与了一项前瞻性研究。LP-CLD组有41例患者，LP组有128例患者，CLD组有98例患者。LP的诊断基于典型的宏观和组织病理学特征，肝病的诊断基于肝脏组织学。对血清样本进行抗HCV抗体筛查。在89名患者中，还检测了血清HCV RNA。抗HCV抗体的总体患病率为29.2%（78/267例患者）。抗HCV阳性患者中96.2%的血清HCV RNA水平呈阳性，抗HCV阴性患者中无一例阳性。LP-CLD组（78%）和CLD组（42.8%）的抗HCV阳性率高于LP组（3.1%）。结论是，HCV感染在与口腔LP相关的CLD中起病因学作用，而根据目前的研究结果，大多数单纯患有口腔LP的患者未感染HCV。
