Oral Medicine Department, School of Dentistry, University of Granada Granada, Paseo de Cartuja s/n, 18071 Granada, Spain
Med Oral Patol Oral Cir Bucal. 2023 May 1;28(3):e229-e237. doi: 10.4317/medoral.25661.
Oral lichen planus (OLP) is a prevalent autoimmune chronic inflammatory disease of unknown etiology. The importance of the association between hepatic disease and OLP lies in the fact that many of these disorders (HC, HB, cirrhosis, hepatic steatosis) behave as risk factors for hepatocellular carcinoma.
We searched PubMed, Embase, Web of Science, and Scopus for studies published before January 2022. We evaluated the quality of studies (Joanna Briggs Institute tool). We performed meta-analyses, investigated the heterogeneity between studies, and we also carried out subgroups, meta-regression, and small-study effects analyses. 146 studies (21,187 patients) were included in this study. Our study aims to evaluate current evidence on the prevalence and magnitude of association between hepatic diseases (especially those with risk of malignancy), hepatocellular carcinoma and OLP.
Our results suggest that patients with OLP present a significant tendency to the development of hepatitis B (OR=1.62, 95%CI=1.01-2.40, p=0.02), hepatitis C (OR=4.09, 95%CI=2.77-6.03, p<0.001), cirrhosis (OR=5.58, 95%CI=1.83-16.96, p=0.002), hepatic steatosis (OR=5.71, 95%CI=0.97-33.60, p=0.05) and hepatocellular carcinoma (OR=3.10,95%CI=1.14-8.43, p=0.03).
Patients with OLP should be investigated to rule out the presence of hepatic disease, which can lead to hepatocellular carcinoma, allowing an early diagnosis that would help to a better approach to liver disease and a notable improvement in prognosis in terms of both progression and severity.
口腔扁平苔藓（OLP）是一种常见的病因不明的自身免疫性慢性炎症性疾病。肝脏疾病与 OLP 之间的关联的重要性在于，许多这些疾病（HC、HB、肝硬化、肝脂肪变性）表现为肝细胞癌的危险因素。
我们在 PubMed、Embase、Web of Science 和 Scopus 上搜索了截至 2022 年 1 月之前发表的研究。我们评估了研究的质量（Joanna Briggs 研究所工具）。我们进行了荟萃分析，研究了研究之间的异质性，还进行了亚组、荟萃回归和小研究效应分析。共有 146 项研究（21,187 名患者）纳入本研究。我们的研究旨在评估当前关于肝脏疾病（特别是具有恶性肿瘤风险的疾病）、肝细胞癌和 OLP 之间患病率和关联程度的证据。
我们的结果表明，OLP 患者有发生乙型肝炎（OR=1.62，95%CI=1.01-2.40，p=0.02）、丙型肝炎（OR=4.09，95%CI=2.77-6.03，p<0.001）、肝硬化（OR=5.58，95%CI=1.83-16.96，p=0.002）、肝脂肪变性（OR=5.71，95%CI=0.97-33.60，p=0.05）和肝细胞癌（OR=3.10，95%CI=1.14-8.43，p=0.03）的显著倾向。
OLP 患者应进行检查以排除肝脏疾病的存在，这可能导致肝细胞癌，并有助于早期诊断，从而改善肝脏疾病的治疗方法，并显著改善疾病的进展和严重程度方面的预后。
