Heyneker H L, Klenow H
Basic Life Sci. 1975;5A:219-23. doi: 10.1007/978-1-4684-2895-7_29.
From comparative studies between Escherichia coli PolA107 cells (lacking 5' in equilibrium 3' exonucleoytic activity associated with DNA polymerase I) and the isogenic wild-type strain, and between the purified DNA polymerase I preparations isolated from these strains, it can be concluded that the 5' in equilibrium 5' exonuclease is involved in excision of pyrimidine dimers in E. coli. Evidence is presented that the polA107 mutation is located on that part of the DNA polymerase I gene coding for the small fragment on which 5' in equilibrium 3' exonucleolytic activity is found.
通过对大肠杆菌PolA107细胞（缺乏与DNA聚合酶I相关的5'平衡3'核酸外切酶活性）与同基因野生型菌株之间，以及从这些菌株中分离出的纯化DNA聚合酶I制剂之间的比较研究，可以得出结论：5'平衡5'核酸外切酶参与大肠杆菌中嘧啶二聚体的切除。有证据表明，polA107突变位于DNA聚合酶I基因中编码小片段的那部分，在该小片段上发现了5'平衡3'核酸外切酶活性。
