Li S X
Department of Pharmacology, Beijing Medical University.
Sheng Li Ke Xue Jin Zhan. 1997 Apr;28(2):129-31.
The influence of three immunoenhancers on animal sleep and their mechanism was studied. Isoprinosine, transfer factor and muramyl dipeptide(MDP) could promote animal immune function, and prolong the sleeping time of mice and rabbits. Tumor necrosis factor (TNF), an immune cytokine, could prolong animal sleep; MDP could increase the synthesis and secretion of TNF from cultured mice astrocytes by promoting the expression of TNF alpha mRNA, resulting in an increase of TNF level in mice brains; monoclone antibody of TNF could partly antagonize the promoting effect of MDP on rabbits sleep. These results suggest that TNF is an important mediator in the influence of immune system on sleep. TNF could increase the turnover rate of 5-HT in mice brains, which may be one of the mechanisms of TNFs' promoting effect on sleep.
研究了三种免疫增强剂对动物睡眠的影响及其机制。异丙肌苷、转移因子和胞壁酰二肽（MDP）可促进动物免疫功能，并延长小鼠和兔子的睡眠时间。肿瘤坏死因子（TNF）作为一种免疫细胞因子，可延长动物睡眠时间；MDP可通过促进TNFα mRNA的表达，增加培养的小鼠星形胶质细胞TNF的合成与分泌，导致小鼠脑内TNF水平升高；TNF单克隆抗体可部分拮抗MDP对兔子睡眠的促进作用。这些结果表明，TNF是免疫系统影响睡眠的重要介质。TNF可提高小鼠脑内5-羟色胺（5-HT）的转换率，这可能是TNF促进睡眠作用的机制之一。
