Padungtod C, Savitz D A, Overstreet J W, Christiani D C, Ryan L M, Xu X
Occupational Health Program, Harvard School of Public Health, Boston, MA 02115, USA.
J Occup Environ Med. 2000 Oct;42(10):982-92. doi: 10.1097/00043764-200010000-00004.
This study investigated the association between occupational pesticide exposure and semen quality among Chinese workers. Male workers, 32 who were exposed to organophosphate pesticides and 43 who were not exposed were recruited from two nearby factories and interviewed. Following a work shift, semen and urine samples were collected for pesticide metabolite analysis. Semen samples were analyzed for sperm concentration, percentage of motility, and percentage of normal structure. Within the exposed group, the mean end-of-shift urinary p-nitrophenol levels were 0.22 and 0.15 mg/L for the high- and low-exposure subgroups, respectively. Linear regression analysis of individual semen parameters revealed a significant reduction of sperm concentration (35.9 x 10(6) vs 62.8 x 10(6), p < 0.01) and percentage of motility (47% vs 57%, p = 0.03) but not percentage of sperm with normal structure (57% vs 61%, p = 0.13). Multivariate modeling showed a significant overall shift in the mean semen parameter. Occupational exposure to ethylparathion and methamidophos seems to have a moderately adverse effect on semen quality.
本研究调查了中国工人职业性接触农药与精液质量之间的关联。从附近两家工厂招募了男性工人，其中32名接触有机磷农药，43名未接触有机磷农药，并对他们进行了访谈。在一个工作日结束后，收集精液和尿液样本进行农药代谢物分析。对精液样本进行精子浓度、活力百分比和正常结构百分比分析。在接触组中，高接触亚组和低接触亚组中班末尿对硝基苯酚水平分别为0.22和0.15mg/L。对个体精液参数进行线性回归分析发现，精子浓度显著降低（35.9×10⁶对62.8×10⁶，p<0.01），活力百分比降低（47%对57%，p = 0.03），但正常结构精子百分比未降低（57%对61%，p = 0.13）。多变量建模显示精液参数均值有显著的总体变化。职业性接触对硫磷和甲胺磷似乎对精液质量有中度不良影响。
