Paterson I C, Cooke N J, Murray K, Crompton G K, Grant I W
Br J Dis Chest. 1975 Jul;69:217-22. doi: 10.1016/0007-0971(75)90083-2.
Three patients with chronic asthma developed pulmonary eosinophilia while oral prednisolone was being withdrawn after the introduction of treatment with beclomethasone dipropionate aerosol. These observations suggest that the development of pulmonary eosinophilia in patients with chronic asthma can be prevented by the systemic administration of corticosteroids, but not by a corticosteroid aerosol given by inhalation. It is considered that radiological examination of the chest should be carried out at frequent intervals during and for a few months after the substitution of corticosteroid aerosol therapy for oral corticosteroid therapy in order to ensure that those patients who are liable to develop pulmonary eosinophilia will be identified at an early stage. These precautions are even more essential when there is a previous history of pulmonary eosinophilia.
三名慢性哮喘患者在开始使用丙酸倍氯米松气雾剂治疗后停用口服泼尼松龙期间出现了肺部嗜酸性粒细胞增多。这些观察结果表明，慢性哮喘患者肺部嗜酸性粒细胞增多的发生可通过全身性给予皮质类固醇来预防，但不能通过吸入皮质类固醇气雾剂来预防。据认为，在将皮质类固醇气雾剂疗法替代口服皮质类固醇疗法期间及之后的几个月内，应定期进行胸部放射学检查，以确保能早期识别那些易于发生肺部嗜酸性粒细胞增多的患者。当有既往肺部嗜酸性粒细胞增多病史时，这些预防措施更为重要。
