Hudgel D W, Spector S L
Chest. 1977 Sep;72(3):359-60. doi: 10.1378/chest.72.3.359.
We present the findings in a young woman diagnosed as having pulmonary infiltration with eosinophilia and asthma who was treated with beclomethasone dipropionate. Although the aerosol corticosteroid controlled bronchospasm, it did not prevent recurrent pulmonary infiltration with eosinophilia when the patient was not receiving oral therapy with corticosteroids. It is postulated that when administered in the usual dosage, an adequate amount of beclomethasone dipropionate does not reach the alveoli or interstitium to prevent or resolve the process of pulmonary infiltration with eosinophilia. This case suggests that patients with pulmonary infiltration and eosinophilia who are treated with inhaled corticosteroids for asthma must be closely observed physiologically or roentgenographically for pulmonary infiltration. These patients may need to be protected from recurrent pulmonary infiltration by the concurrent oral use of corticosteroids.
我们报告了一名被诊断为嗜酸性粒细胞性肺浸润和哮喘的年轻女性患者的治疗结果，该患者接受了二丙酸倍氯米松治疗。尽管气雾剂皮质类固醇可控制支气管痉挛，但在患者未接受口服皮质类固醇治疗时，它并不能预防嗜酸性粒细胞性肺浸润的复发。据推测，按常规剂量给药时，适量的二丙酸倍氯米松无法到达肺泡或间质，以预防或解决嗜酸性粒细胞性肺浸润的过程。该病例表明，对于因哮喘接受吸入性皮质类固醇治疗的嗜酸性粒细胞性肺浸润患者，必须进行密切的生理或影像学观察以监测肺浸润情况。这些患者可能需要同时口服皮质类固醇以防止肺浸润复发。
