Steffey E P, Pascoe P J, Woliner M J, Berryman E R
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA.
Am J Vet Res. 2000 Oct;61(10):1225-31. doi: 10.2460/ajvr.2000.61.1225.
To quantitate dose- and time-related anesthetic-sparing effects of xylazine hydrochloride (XYL) during isoflurane-induced anesthesia in horses and to characterize selected physiologic responses of anesthetized horses to administration of XYL.
6 healthy adult horses.
Horses were anesthetized 2 times to determine the minimum alveolar concentration (MAC) of isoflurane in O2 and to characterize the anesthetic-sparing effect (MAC reduction) after IV administration of XYL (0.5 and 1 mg/kg of body weight, random order). Selected measures of cardiopulmonary function, blood glucose concentrations, and urinary output also were measured during the anesthetic studies.
Isoflurane MAC (mean +/- SEM) was reduced by 24.8 +/- 0.5 and 34.2 +/- 1.9% at 42 +/- 7 and 67 +/- 10 minutes, respectively, after administration of XYL at 0.5 and 1 mg/kg. Amount of MAC reduction by XYL was dose- and time-dependent. Overall, cardiovascular and respiratory values varied little among treatments. Administration of XYL increased blood glucose concentration; the magnitude of change was dose- and time-dependent. Urine volume increased but not significantly.
Administration of XYL reduced the anesthetic requirement for isoflurane in horses. The magnitude of the decrease is dose- and time-dependent. Administration of XYL increases blood glucose concentration in anesthetized horses in a dose-related manner.
定量研究盐酸赛拉嗪（XYL）在马匹异氟烷诱导麻醉期间与剂量和时间相关的麻醉节省效应，并描述麻醉马匹对XYL给药的选定生理反应。
6匹健康成年马。
对马匹进行2次麻醉，以确定异氟烷在氧气中的最低肺泡浓度（MAC），并表征静脉注射XYL（0.5和1mg/kg体重，随机顺序）后的麻醉节省效应（MAC降低）。在麻醉研究期间还测量了选定的心肺功能指标、血糖浓度和尿量。
在分别以0.5和1mg/kg的剂量给予XYL后，异氟烷MAC（平均值±标准误）在42±7分钟和67±10分钟时分别降低了24.8±0.5%和34.2±1.9%。XYL降低MAC的量呈剂量和时间依赖性。总体而言，各治疗组之间的心血管和呼吸值变化不大。XYL给药使血糖浓度升高；变化幅度呈剂量和时间依赖性。尿量增加但不显著。
XYL给药降低了马匹对异氟烷的麻醉需求。降低幅度呈剂量和时间依赖性。XYL给药以剂量相关的方式增加麻醉马匹的血糖浓度。
