Simhi E, van der Mei H C, Ron E Z, Rosenberg E, Busscher H J
Schneider Children's Medical Center of Israel, Petah-Tikva, Israel.
FEMS Microbiol Lett. 2000 Nov 1;192(1):97-100. doi: 10.1111/j.1574-6968.2000.tb09365.x.
Catheter-associated urinary tract infection is the most common nosocomial infection, and contributes to patient morbidity and mortality. We investigated the effect that the TA adhesive antibiotic had on adhesion and initial growth in urine of Escherichia coli on silicone rubber. The TA antibiotic had reduced adhesion, and inhibited initial growth of the bacteria on the surface. Since adhesion and initial growth on the surface are an essential part of biofilm formation and subsequent infection, we speculate that the TA antibiotic coating might decrease the infection rate associated with indwelling urinary catheter.
导尿管相关尿路感染是最常见的医院感染，会导致患者发病和死亡。我们研究了TA黏附性抗生素对大肠杆菌在硅橡胶上尿液中的黏附及初始生长的影响。TA抗生素降低了黏附，并抑制了细菌在表面的初始生长。由于表面黏附及初始生长是生物膜形成及后续感染的重要组成部分，我们推测TA抗生素涂层可能会降低与留置导尿管相关的感染率。
