丙戊酸钠治疗严重癫痫的对照试验。
Controlled trial of sodium valproate in severe epilepsy.
作者信息
Richens A, Ahmad S
出版信息
Br Med J. 1975 Nov 1;4(5991):255-6. doi: 10.1136/bmj.4.5991.255.
Abstract
In a double-blind crossover trial sodium valproate or placebo was added to the existing anticonvulsant treatment of 20 patients with chronic uncontrolled epilepsy. Sodium valproate 1200 mg/day significantly reduced the frequency of both tonic-clonic and minor seizures in these patients. Only mild and transient side effects occurred (drowsiness, ataxia, and nausea), and these may have been due to the effect of adding sodium valproate to existing phenobarbitone or phenytoin treatment. Further controlled trials are needed to assess more fully the efficacy of this drug in various types of epilepsy.
摘要
在一项双盲交叉试验中，对20例慢性癫痫控制不佳的患者，在其现有的抗惊厥治疗基础上加用丙戊酸钠或安慰剂。丙戊酸钠1200毫克/天可显著降低这些患者强直阵挛性发作和小发作的频率。仅出现了轻微且短暂的副作用（嗜睡、共济失调和恶心），这些可能是由于在现有的苯巴比妥或苯妥英治疗基础上加用丙戊酸钠所致。需要进一步的对照试验来更全面地评估该药物在各种类型癫痫中的疗效。
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