丙戊酸钠与氯硝西泮治疗慢性癫痫的对比试验。

Comparative trial of valproate sodium and clonazepam in chronic epilepsy.

作者信息

Shakir R A, Nanda R N, Lambie D G, Johnson R H

出版信息

Arch Neurol. 1979 May;36(5):301-4. doi: 10.1001/archneur.1979.00500410079012.

DOI:10.1001/archneur.1979.00500410079012

Abstract

A crossover comparative study of valproate sodium and clonazepam in the treatment of 32 adult epileptic patients receiving multiple drug therapy is described. Serum concentrations of other anticonvulsant drugs were unchanged by the addition of clonazepam. However, patients receiving high doses of other anticonvulsant drugs had lower serum concentrations of clonazepam (p less than .01). With valproate sodium, phenobarbital concentrations increased (P less than .05) in patients receiving phenobarbital but not significantly in patients receiving primidone. Phenytoin concentrations were reduced (P less than .05) during treatment with valproate sodium. Both drugs significantly reduced the frequency of minor seizures, with valproate sodium having the greater effect. However, it is important to monitor serum concentrations of other anticonvulsant drugs during treatment with valproate sodium since changes in these may influence seizure control or cause side effects.

摘要

本文描述了一项交叉对照研究，该研究针对32名接受多种药物治疗的成年癫痫患者，比较了丙戊酸钠和氯硝西泮的治疗效果。添加氯硝西泮后，其他抗惊厥药物的血清浓度未发生变化。然而，接受高剂量其他抗惊厥药物治疗的患者，其氯硝西泮血清浓度较低（p<0.01）。使用丙戊酸钠时，接受苯巴比妥治疗的患者，其苯巴比妥浓度升高（P<0.05），而接受扑米酮治疗的患者，其苯巴比妥浓度升高不显著。在丙戊酸钠治疗期间，苯妥英浓度降低（P<0.05）。两种药物均能显著降低轻度癫痫发作的频率，其中丙戊酸钠的效果更佳。然而，在丙戊酸钠治疗期间，监测其他抗惊厥药物的血清浓度非常重要，因为这些药物浓度的变化可能会影响癫痫控制或导致副作用。