小剂量肝素预防致死性肺栓塞
Low-dose heparin prophylaxis against fatal pulmonary embolism.
作者信息
Sagar S, Massey J, Sanderson J M
出版信息
Br Med J. 1975 Nov 1;4(5991):257-9. doi: 10.1136/bmj.4.5991.257.
Abstract
A prospective randomised controlled trial in 500 patients over the age of 50 who were undergoing major surgery showed that low-dose subcutaneous heparin was an effective prophylactic measure against fatal pulmonary embolism. None of the 252 patients who received perioperative heparin cover died of fatal pulmonary embolism while eight of the 236 who did not receive heparin prophylaxis died of fatal pulmonary embolism. These results were statiscally significant (P less than 0.01).
摘要
一项针对500名年龄超过50岁且正在接受大手术患者的前瞻性随机对照试验表明，低剂量皮下注射肝素是预防致命性肺栓塞的有效措施。在252名接受围手术期肝素覆盖的患者中，无人死于致命性肺栓塞，而在236名未接受肝素预防的患者中，有8人死于致命性肺栓塞。这些结果具有统计学意义（P小于0.01）。
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