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小剂量肝素预防致死性肺栓塞

Low-dose heparin prophylaxis against fatal pulmonary embolism.

作者信息

Sagar S, Massey J, Sanderson J M

出版信息

Br Med J. 1975 Nov 1;4(5991):257-9. doi: 10.1136/bmj.4.5991.257.

DOI:10.1136/bmj.4.5991.257
PMID:1104060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1675117/
Abstract

A prospective randomised controlled trial in 500 patients over the age of 50 who were undergoing major surgery showed that low-dose subcutaneous heparin was an effective prophylactic measure against fatal pulmonary embolism. None of the 252 patients who received perioperative heparin cover died of fatal pulmonary embolism while eight of the 236 who did not receive heparin prophylaxis died of fatal pulmonary embolism. These results were statiscally significant (P less than 0.01).

摘要

一项针对500名年龄超过50岁且正在接受大手术患者的前瞻性随机对照试验表明，低剂量皮下注射肝素是预防致命性肺栓塞的有效措施。在252名接受围手术期肝素覆盖的患者中，无人死于致命性肺栓塞，而在236名未接受肝素预防的患者中，有8人死于致命性肺栓塞。这些结果具有统计学意义（P小于0.01）。

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Low-dose heparin prophylaxis against fatal pulmonary embolism.小剂量肝素预防致死性肺栓塞
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2
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本文引用的文献

1
Prevention of postoperative leg vein thrombosis by electrical muscle stimulation. An evaluation with 125I-labelled fibrinogen.通过电肌肉刺激预防术后腿部静脉血栓形成。用125I标记纤维蛋白原进行评估。
Br Med J. 1970 Sep 12;3(5723):615-8. doi: 10.1136/bmj.3.5723.615.
2
Prevention of early postoperative deep vein thrombosis by passive exercise of leg during surgery.手术期间通过腿部被动运动预防术后早期深静脉血栓形成
Br Med J. 1971 Jul 10;3(5766):82-3. doi: 10.1136/bmj.3.5766.82.
3
Prevention of thrombosis after pelvic surgery by British dextran 70.
Lancet. 1972 Mar 18;1(7751):614-6. doi: 10.1016/s0140-6736(72)90410-2.
4
Low doses of heparin in prevention of deep-vein thrombosis.
Lancet. 1971 Sep 25;2(7726):669-71. doi: 10.1016/s0140-6736(71)92244-6.