Godzhaev N M, Agaeva G A
Rasulzade Baku State University, Azerbaijan.
Biofizika. 2000 Jul-Aug;45(4):581-5.
The spatial structures of human immunoglobulin E pentapeptide Asp-Ser-Asp-Pro-Arg and some of its related peptides were investigated by the method of theoretical conformational analysis. These synthetic peptides have the capacity to inhibit the binding of immunoglobulin E to the mast cells of the skin. The results of the calculations and the data on biological activity of these peptides were used for determination their energy-dependent conformational characteristics that provide their specific interaction with receptors of mast cells.
采用理论构象分析方法研究了人免疫球蛋白E五肽天冬氨酸-丝氨酸-天冬氨酸-脯氨酸-精氨酸及其一些相关肽的空间结构。这些合成肽具有抑制免疫球蛋白E与皮肤肥大细胞结合的能力。计算结果和这些肽的生物活性数据被用于确定其能量依赖性构象特征，这些特征决定了它们与肥大细胞受体的特异性相互作用。
