Alovskaia A A, Safronova V G, Kornilov V V, Kornev A N, Savochkina Iu M, Kraupenhaar R, Betzel K, Voelter W, Mikhaĭlov A M
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Biofizika. 2000 Jul-Aug;45(4):688-94.
The ability of viscum at different concentrations to modulate the respiratory burst in neutrophils, induced by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine was studied. This does not exclude the possibility that viscum can interact with the receptor of this peptide. The analysis of the primary structure of viscum revealed elements structurally analogous to the chemotactic peptide. It is assumed that viscum can exhibit the properties an antagonist of the receptor of N-formyl-methionyl-leucyl-phenylalanine, and the mechanism of action of viscum depends on its concentration.
研究了不同浓度的槲寄生对趋化肽N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸诱导的中性粒细胞呼吸爆发的调节能力。这并不排除槲寄生可能与该肽的受体相互作用的可能性。对槲寄生一级结构的分析揭示了与趋化肽结构类似的元件。据推测，槲寄生可能表现出N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸受体拮抗剂的特性，且槲寄生的作用机制取决于其浓度。
