[分辨率为2.2埃和2.9埃的两种晶体形式的抗人白细胞介素-2单克隆抗体Fab片段的空间结构]
[Spatial structure of a Fab-fragment of a monoclonal antibody to human interleukin-2 in two crystalline forms at a resolution of 2.2 and 2.9 angstroms].
作者信息
Fokin A V, Afonin P V, Mikhaĭlova I Iu, Tsygannik I N, Mareeva T Iu, Nesmeianov V A, Pangborn W, Lee N, Duax W, Siszak E, Pletnev V Z
机构信息
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
出版信息
Bioorg Khim. 2000 Aug;26(8):571-8.
PMID:11040993
Abstract
The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 A resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.
摘要
采用分子置换X射线方法，在2.2埃和2.9埃分辨率下，以两种晶体形式测定了抗人白细胞介素-2单克隆抗体抗原结合片段的三维结构。分析了该蛋白质的空间结构及其抗原结合位点的立体化学。
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