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在大鼠牙齿发育的主要萌出前阶段,当主要给予氟化钠、氟化铵和氟化钡时,大鼠牙齿对氟的摄取比较。

Comparative uptake of fluoride from sodium fluoride, ammonium fluoride, and barium fluoride in rat teeth when predominantly administered in the pre-eruptive stage of development.

作者信息

Jech J A

出版信息

Calcif Tissue Int. 1979 Apr 17;27(2):117-9. doi: 10.1007/BF02441172.

DOI:10.1007/BF02441172
PMID:110413
Abstract

A comparative study was undertaken which focused on the systemic uptake of sodium fluoride (NaF), ammonium fluoride (NH4F), and barium fluoride (BaF2) in rat pups. Two critical achievements made this comparative study possible: (a) the demonstration of significant increases in fluoride (F) uptake-deposition in the treatment group pups relative to control group rats as a result of stomach tube feeding; and (b) the demonstration of clear-cut differences in F concentration levels between the treatment groups as a result of this stomach tube-systemic uptake. Data were reliable and significant enough to suggest that, of the 3 compounds in question, NH4F is absorbed most successfully in a systemic fashion, whereas BaF2 is the least absorbed.

摘要

进行了一项比较研究,重点关注幼鼠对氟化钠(NaF)、氟化铵(NH4F)和氟化钡(BaF2)的全身摄取情况。两项关键成果使得这项比较研究成为可能:(a)通过胃管喂食证明,与对照组大鼠相比,治疗组幼鼠的氟(F)摄取沉积显著增加;(b)通过这种胃管全身摄取,证明了各治疗组之间F浓度水平存在明显差异。数据可靠且具有足够的显著性,表明在所研究的3种化合物中,NH4F以全身方式吸收最为成功,而BaF2吸收最少。

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本文引用的文献

1
A technique for tube-feeding newborn rats, and the effects of administration of various carbohydrate solutions on their subsequent caries susceptibility.一种给新生大鼠进行管饲的技术,以及给予各种碳水化合物溶液对其后续龋齿易感性的影响。
Caries Res. 1971;5(2):144-50. doi: 10.1159/000259742.