Bawden J W, McLean P, Deaton T G
J Dent Res. 1986 Jan;65(1):34-8. doi: 10.1177/00220345860650010501.
Suckling rat pups were given intraperitoneal fluoride injections at selected ages so that we could study fluoride uptake in the enamel of the maxillary first molar at various stages of enamel development. Plasma fluoride levels in six-day-old and 11-day-old pups were monitored following the intraperitoneal injection of fluoride. The findings indicate that: (1) fluoride was more easily taken up and retained during the early stages of enamel formation, but fluoride uptake can occur during all stages of enamel formation; (2) when injections were started early in enamel formation, more fluoride was contained in the enamel of the maxillary first molar at 13 days of age; and (3) the same dose of fluoride per gram body weight resulted in greater exposure to elevated plasma fluoride levels in six-day-old pups than in 11-day-old pups.
在特定年龄段给乳鼠幼崽腹腔注射氟化物，以便我们能够研究上颌第一磨牙牙釉质在牙釉质发育各阶段对氟的摄取情况。在腹腔注射氟化物后，监测6日龄和11日龄幼崽的血浆氟水平。研究结果表明：（1）在牙釉质形成的早期阶段，氟更容易被摄取和保留，但在牙釉质形成的所有阶段都可能发生氟摄取；（2）在牙釉质形成早期开始注射时，13日龄上颌第一磨牙的牙釉质中含有的氟更多；（3）每克体重相同剂量的氟化物导致6日龄幼崽的血浆氟水平升高的暴露量比11日龄幼崽更大。
