Houston F, Foster J D, Chong A, Hunter N, Bostock C J
Lancet. 2000 Sep 16;356(9234):999-1000. doi: 10.1016/s0140-6736(00)02719-7.
We have shown that it is possible to transmit bovine spongiform encephalopathy (BSE) to a sheep by transfusion with whole blood taken from another sheep during the symptom-free phase of an experimental BSE infection. BSE and variant Creutzfeldt-Jakob disease (vCJD) In human beings are caused by the same infectious agent, and the sheep-BSE experimental model has a similar pathogenesis to that of human vCJD. Although UK blood transfusions are leucodepleted--a possible protective measure against any risk from blood transmission--this report suggests that blood donated by symptom-free vCJD-infected human beings may represent a risk of spread of vCJD infection among the human population of the UK.
我们已经证明，在实验性牛海绵状脑病（BSE）感染的无症状阶段，通过输注取自另一只绵羊的全血，有可能将BSE传播给一只绵羊。人类的BSE和变异型克雅氏病（vCJD）由相同的传染因子引起，绵羊-BSE实验模型与人类vCJD具有相似的发病机制。尽管英国的输血制品经过白细胞过滤——这是防范血液传播任何风险的一种可能的保护措施——但本报告表明，无症状的vCJD感染者捐献的血液可能会造成vCJD感染在英国人群中传播的风险。
