育亨宾可改善内毒素对马液体标记物对乙酰氨基酚胃排空的影响。
Yohimbine ameliorates the effects of endotoxin on gastric emptying of the liquid marker acetaminophen in horses.
作者信息
Meisler S D, Doherty T J, Andrews F M, Osborne D, Frazier D L
机构信息
Department of Large Animal Clinical Sciences, The University of Tennessee, College of Veterinary Medicine, Knoxville, 37901-1071, USA.
出版信息
Can J Vet Res. 2000 Oct;64(4):208-11.
The effect of yohimbine pretreatment on gastric emptying of a liquid marker in horses was evaluated by measuring serum concentrations of acetaminophen. Gastric emptying was determined in normal, fasted horses, in horses given endotoxin (E. coli 055 B5; 0.2 microg/kg) intravenously, and in horses given yohimbine (0.25 mg/kg, IV, over 30 minutes) plus endotoxin. Acetaminophen (20 mg/kg) was given by stomach tube 15 minutes after the endotoxin infusion. Blood samples for acetaminophen analysis were collected, and time to reach the peak serum concentration (Tmax), the maximum serum concentration (Cmax) and the area under the acetaminophen serum concentration versus time curve (AUC) were determined for each treatment group. Endotoxin significantly increased Tmax, indicating a profound delay in gastric emptying and yohimbine pretreatment significantly (P < or = 0.05) prevented this effect.
通过测量对乙酰氨基酚的血清浓度，评估育亨宾预处理对马液体标记物胃排空的影响。在正常禁食马、静脉注射内毒素（大肠杆菌055 B5；0.2微克/千克）的马以及注射育亨宾（0.25毫克/千克，静脉注射，30分钟以上）加内毒素的马中测定胃排空情况。在内毒素输注15分钟后，通过胃管给予对乙酰氨基酚（20毫克/千克）。采集用于对乙酰氨基酚分析的血样，确定每个治疗组达到血清峰值浓度的时间（Tmax）、最大血清浓度（Cmax）以及对乙酰氨基酚血清浓度与时间曲线下的面积（AUC）。内毒素显著增加了Tmax，表明胃排空严重延迟，而育亨宾预处理显著（P≤0.05）阻止了这种影响。
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