保泰松可防止内毒素引起的马匹胃排空延迟。
Phenylbutazone prevents the endotoxin-induced delay in gastric emptying in horses.
作者信息
Valk N, Doherty T J, Blackford J T, Abraha T W, Frazier D L
机构信息
Department of Large Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville 37901-1071, USA.
出版信息
Can J Vet Res. 1998 Jul;62(3):214-7.
The effect of phenylbutazone on gastric emptying in horses was determined by measuring serum concentrations of acetaminophen. Gastric emptying was determined in normal fasted horses (n = 6), horses given endotoxin intravenously (n = 6), horses given intravenous phenylbutazone (n = 6), and horses given intravenous phenylbutazone plus endotoxin (n = 6). The mean time to reach maximum serum acetaminophen concentration (Tmax), the maximum serum concentration (Cmax), and the area under the serum acetaminophen concentration versus time curve (AUC) were compared among treatment groups. Phenylbutazone did not alter gastric emptying in normal horses. Endotoxin caused a profound delay in gastric emptying, and pretreatment with phenylbutazone abolished this effect.
通过测量对乙酰氨基酚的血清浓度来确定保泰松对马胃排空的影响。在正常禁食的马（n = 6）、静脉注射内毒素的马（n = 6）、静脉注射保泰松的马（n = 6）以及静脉注射保泰松加内毒素的马（n = 6）中测定胃排空情况。比较各治疗组达到血清对乙酰氨基酚最大浓度的平均时间（Tmax）、最大血清浓度（Cmax）以及血清对乙酰氨基酚浓度-时间曲线下面积（AUC）。保泰松未改变正常马的胃排空。内毒素导致胃排空显著延迟，而保泰松预处理可消除这种作用。
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