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本文引用的文献

1
Acetaminophen as a marker of gastric emptying in ponies.对乙酰氨基酚作为马驹胃排空的标志物。
Equine Vet J. 1998 Jul;30(4):349-51. doi: 10.1111/j.2042-3306.1998.tb04109.x.
2
Effect of cisapride on gastric emptying in horses following endotoxin treatment.
Equine Vet J. 1998 Jul;30(4):344-8. doi: 10.1111/j.2042-3306.1998.tb04108.x.
3
Antagonism of endotoxin-induced disruption of equine bowel motility by flunixin and phenylbutazone.氟尼辛和保泰松对内毒素诱导的马肠道运动紊乱的拮抗作用。
Equine Vet J Suppl. 1989 Jun(7):38-42. doi: 10.1111/j.2042-3306.1989.tb05653.x.
4
Effect of bethanechol or erythromycin on gastric emptying in horses.
Am J Vet Res. 1996 Dec;57(12):1771-5.
5
Effect of endotoxemia on intestinal villus microcirculation in rats.
J Surg Res. 1996 Mar;61(2):521-6. doi: 10.1006/jsre.1996.0157.
6
Blockade of endotoxin-induced cecal hypoperfusion and ileus with an alpha 2 antagonist in horses.α2拮抗剂对马内毒素诱导的盲肠低灌注和肠梗阻的阻断作用
Am J Vet Res. 1993 Apr;54(4):586-90.
7
Gastric emptying of four liquid meals in pony foals.
Res Vet Sci. 1994 Mar;56(2):164-9. doi: 10.1016/0034-5288(94)90099-x.
8
Prevention of endotoxin-induced arterial hypoxaemia and lactic acidosis with flunixin meglumine in the conscious pony.氟尼辛葡甲胺对清醒小马驹内毒素诱导的动脉低氧血症和乳酸酸中毒的预防作用
Equine Vet J. 1981 Apr;13(2):95-8. doi: 10.1111/j.2042-3306.1981.tb04122.x.
9
Neostigmine methylsulfate delays gastric emptying of particulate markers in horses.
Am J Vet Res. 1985 Dec;46(12):2498-9.
10
Effect of vasopressors on organ blood flow during endotoxin shock in pigs.
Am J Physiol. 1987 Feb;252(2 Pt 2):H291-300. doi: 10.1152/ajpheart.1987.252.2.H291.

保泰松可防止内毒素引起的马匹胃排空延迟。

Phenylbutazone prevents the endotoxin-induced delay in gastric emptying in horses.

作者信息

Valk N, Doherty T J, Blackford J T, Abraha T W, Frazier D L

机构信息

Department of Large Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville 37901-1071, USA.

出版信息

Can J Vet Res. 1998 Jul;62(3):214-7.

PMID:9684051
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1189478/
Abstract

The effect of phenylbutazone on gastric emptying in horses was determined by measuring serum concentrations of acetaminophen. Gastric emptying was determined in normal fasted horses (n = 6), horses given endotoxin intravenously (n = 6), horses given intravenous phenylbutazone (n = 6), and horses given intravenous phenylbutazone plus endotoxin (n = 6). The mean time to reach maximum serum acetaminophen concentration (Tmax), the maximum serum concentration (Cmax), and the area under the serum acetaminophen concentration versus time curve (AUC) were compared among treatment groups. Phenylbutazone did not alter gastric emptying in normal horses. Endotoxin caused a profound delay in gastric emptying, and pretreatment with phenylbutazone abolished this effect.

摘要

通过测量对乙酰氨基酚的血清浓度来确定保泰松对马胃排空的影响。在正常禁食的马(n = 6)、静脉注射内毒素的马(n = 6)、静脉注射保泰松的马(n = 6)以及静脉注射保泰松加内毒素的马(n = 6)中测定胃排空情况。比较各治疗组达到血清对乙酰氨基酚最大浓度的平均时间(Tmax)、最大血清浓度(Cmax)以及血清对乙酰氨基酚浓度-时间曲线下面积(AUC)。保泰松未改变正常马的胃排空。内毒素导致胃排空显著延迟,而保泰松预处理可消除这种作用。