利用工程菌大规模生产低聚糖。
Large-scale production of oligosaccharides using engineered bacteria.
作者信息
Endo T, Koizumi S
机构信息
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co Ltd, 3-6-6, Asahi-machi, Machida-shi, 194-8533, Tokyo, Japan.
出版信息
Curr Opin Struct Biol. 2000 Oct;10(5):536-41. doi: 10.1016/s0959-440x(00)00127-5.
Abstract
Rapid advances in the cloning and expression of glycosyltransferase genes, especially from bacteria, could open the way to overcoming difficulties in the mass production of oligosaccharides. The large-scale production of oligosaccharides using either glycosyltransferases isolated from engineered microorganisms or whole cells as an enzyme source could promote a new era in the field of carbohydrate synthesis.
摘要
糖基转移酶基因的克隆与表达取得了快速进展，尤其是来自细菌的基因，这可能为克服寡糖大规模生产中的困难开辟道路。利用从工程微生物中分离的糖基转移酶或全细胞作为酶源大规模生产寡糖，可能会开创碳水化合物合成领域的新纪元。
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