Shbarou R M, Chao N J, Morgenlander J C
Division of Pediatric Neurology, Duke University Medical Center, Durham, NC 27710, USA.
Bone Marrow Transplant. 2000 Oct;26(7):801-4. doi: 10.1038/sj.bmt.1702603.
The use of cyclosporin A has been associated with several side-effects, including neurotoxicity. The mechanism of toxicity is not well known. We report two patients treated with cyclosporin A who developed lesions in the cerebral white matter associated with abnormally elevated cerebral blood flow velocities on transcranial doppler ultrasound and abnormal vascular appearance on magnetic resonance angiography. Bone Marrow Transplantation (2000) 26, 801-804.
环孢素A的使用与多种副作用相关，包括神经毒性。毒性机制尚不清楚。我们报告了两名接受环孢素A治疗的患者，他们在脑白质出现病变，经颅多普勒超声显示脑血流速度异常升高，磁共振血管造影显示血管外观异常。《骨髓移植》（2000年）第26卷，第801 - 804页。
