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血管痉挛是环孢素诱导神经毒性的重要因素：病例报告。

Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: case report.

机构信息

Department of Neurology, Maastricht University Medical Centre, Maastricht, the Netherlands.

出版信息

BMC Neurol. 2010 May 11;10:30. doi: 10.1186/1471-2377-10-30.

DOI:10.1186/1471-2377-10-30
PMID:20459819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2874792/
Abstract

BACKGROUND

The aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial.

CASE PRESENTATION

We report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes while on cyclosporine treatment.Transcranial Doppler ultrasound revealed severely elevated flow velocities in several cerebral vessels, consistent with vasospasm. Immediately after reducing the cyclosporine dose, the stroke-like episodes disappeared. Only after cyclosporine withdrawal the transcranial Doppler ultrasound abnormalities fully resolved.

CONCLUSIONS

This case demonstrates a significant role of vasospasm in the pathway of cyclosporine-induced neurotoxicity. Transcranial Doppler ultrasound is an effective tool for the diagnosis and follow-up of cyclosporine-induced vasospasm.

摘要

背景

中枢神经系统病变的病因在环孢素神经毒性中仍存在争议。

病例介绍

我们报告了一名 48 岁女性，患有非严重再生障碍性贫血，在环孢素治疗期间出现类似中风的发作。经颅多普勒超声显示多个脑动脉血流速度严重升高，符合血管痉挛。在减少环孢素剂量后，类似中风的发作立即消失。只有在停用环孢素后，经颅多普勒超声异常才完全消退。

结论

该病例表明血管痉挛在环孢素诱导的神经毒性途径中起重要作用。经颅多普勒超声是诊断和随访环孢素诱导的血管痉挛的有效工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a02b/2874792/c26d3b90c158/1471-2377-10-30-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a02b/2874792/b41eb70dcaae/1471-2377-10-30-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a02b/2874792/8152d5cf288b/1471-2377-10-30-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a02b/2874792/c26d3b90c158/1471-2377-10-30-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a02b/2874792/b41eb70dcaae/1471-2377-10-30-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a02b/2874792/8152d5cf288b/1471-2377-10-30-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a02b/2874792/c26d3b90c158/1471-2377-10-30-3.jpg

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