肿瘤学中使用2-[18F]氟-2-脱氧-D-葡萄糖的正电子发射断层扫描。第二部分。检测和分期原发性肿瘤的临床价值。
Positron emission tomography with 2-[18F]fluoro-2-deoxy-D-glucose in oncology. Part II. The clinical value in detecting and staging primary tumours.
作者信息
Ak I, Stokkel M P, Pauwels E K
机构信息
Leiden University, Medical Centre, Department of Radiology, The Netherlands.
出版信息
J Cancer Res Clin Oncol. 2000 Oct;126(10):560-74. doi: 10.1007/pl00008466.
Abstract
The tumoral uptake of 2-[18F]fluoro-2-deoxy-D-glucose (18FdGlc) is based upon enhanced glycolysis. Positron-emission tomography (PET) using 18FdGlc provides the physiological and metabolic information. 18FdGlc PET has been used successfully for assessing primary tumours and metastases, prognosis, and planning and for monitoring tumour therapy as well as for early detection of recurrent tumour growth. This review summarises the uptake mechanism of 18FdGlc in benign and malignant lesions, its relation to histopathology, and its clinical value for detecting and staging primary tumours.
摘要
2-[¹⁸F]氟-2-脱氧-D-葡萄糖（¹⁸FdGlc）的肿瘤摄取基于糖酵解增强。使用¹⁸FdGlc的正电子发射断层扫描（PET）可提供生理和代谢信息。¹⁸FdGlc PET已成功用于评估原发性肿瘤和转移灶、预后、治疗规划以及监测肿瘤治疗，还可用于早期检测复发性肿瘤生长。本综述总结了¹⁸FdGlc在良性和恶性病变中的摄取机制、其与组织病理学的关系以及其在检测原发性肿瘤和分期方面的临床价值。
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