Yumita N, Nishigaki R, Umemura S
School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan.
J Cancer Res Clin Oncol. 2000 Oct;126(10):601-6. doi: 10.1007/pl00008471.
The sonodynamically induced antitumor effect of Photofrin II (PF), was evaluated in mice bearing colon 26 carcinoma. In order to find the optimum timing for ultrasonic exposure after the administration of PF, the PF concentrations in the plasma, skin, muscle, and tumor were measured. The antitumor effect was estimated by measuring the tumor size. Since the highest concentration of PF in the tumor was observed 24 h after administration, an ultrasonic exposure timing of 24 h after the intravenous administration of PF was chosen. When used alone, ultrasound showed a slight antitumor effect, which became increasingly significant as the dose of PF was increased, while use of PF alone showed no significant effect. From these results, it is concluded that PF significantly sensitizes solid tumors to ultrasound, demonstrating a synergistic antitumor effect.
在荷结肠26癌的小鼠中评估了血卟啉II（PF）的声动力诱导抗肿瘤作用。为了找到给予PF后超声暴露的最佳时间，测量了血浆、皮肤、肌肉和肿瘤中的PF浓度。通过测量肿瘤大小来评估抗肿瘤作用。由于给药后24小时观察到肿瘤中PF浓度最高，因此选择在静脉注射PF后24小时进行超声暴露。单独使用超声时显示出轻微的抗肿瘤作用，随着PF剂量的增加，这种作用变得越来越显著，而单独使用PF则没有显著效果。从这些结果可以得出结论，PF能显著使实体瘤对超声敏感，显示出协同抗肿瘤作用。
