Yumita N, Sasaki K, Umemura S, Nishigaki R
School of Pharmaceutical Sciences, Toho University, Chiba.
Jpn J Cancer Res. 1996 Mar;87(3):310-6. doi: 10.1111/j.1349-7006.1996.tb00222.x.
The sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70, was evaluated in mice bearing colon 26. In order to find the optimum timing for the ultrasonic exposure after the administration of ATX-70, the ATX-70 concentrations in the plasma, skin, and tumor were measured and analyzed. Antitumor effect was estimated by measuring the tumor size. When used alone, ultrasound showed a slight antitumor effect, which became increasingly significant as the dose of ATX-70 was increased, while use of ATX-70 alone had no significant effect. At an ATX-70 dose of 2.5 mg/kg or higher, the average tumor size decreased to smaller than a half by three days after the ultrasonic exposure. This was smaller than a third of the size of the untreated tumors on the same day. From these results, it is concluded that ATX-70 significantly sensitizes tumors to ultrasound, demonstrating a synergistic antitumor effect.
在携带结肠26肿瘤的小鼠中评估了镓卟啉复合物ATX - 70的声动力诱导抗肿瘤作用。为了找到给予ATX - 70后超声照射的最佳时间，对血浆、皮肤和肿瘤中的ATX - 70浓度进行了测量和分析。通过测量肿瘤大小来评估抗肿瘤效果。单独使用超声时显示出轻微的抗肿瘤作用，随着ATX - 70剂量的增加，这种作用变得越来越显著，而单独使用ATX - 70则没有显著效果。在ATX - 70剂量为2.5mg/kg或更高时，超声照射三天后平均肿瘤大小减小至不到原来的一半。这比同一天未治疗肿瘤大小的三分之一还小。从这些结果可以得出结论，ATX - 70能显著使肿瘤对超声敏感，表现出协同抗肿瘤作用。
